DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRIM25 and brat

DIOPT Version :9

Sequence 1:	NP_005073.2	Gene:	TRIM25 / 7706	HGNCID:	12932	Length:	630	Species:	Homo sapiens
Sequence 2:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	78/397 - (19%)
Similarity:	128/397 - (32%)	Gaps:	120/397 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    29 GHNFCGSCLNETWAVQGSPYLCPQCRA--------VYQARPQLHKNTVLCNVVEQFL------QA 79
            |.|...:..:...:..|||..|..|::        .::.:..|..|   |....:|:      ..
  Fly   158 GSNSSSNSSSSNTSANGSPPRCTACKSKCSDAVAKCFECQSYLCAN---CVTAHEFMHCFNGHNV 219

Human    80 DLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVKTCL------------------------ 120
            .|.:...|.....|....:||.|   ...:..|.|:..|.:
  Fly   220 CLIKGFEASTTGTPLSVGSPSNN---PASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPM 281

Human   121 -----VCMASFCQEHL--QPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSE----- 173
                 :.:|:..|.:.  |...||.....||.|        ::..|..:.|:.|||.|.:
  Fly   282 SQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQ--------QQQQQQQQQRQLFCPRHKQELLKF 338

Human   174 -----CI--CHICLV-EHK--------------TCSPASLSQASA--DLEATLRHKLTVMYSQIN 214
                 ||  |..|:| ||.              |.|..|.:..||  .|.|.:|.|:..:.....
  Fly   339 SCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAG 403

Human   215 GASRALDDVRNRQQDVRMTANRKVEQLQQEYTEM-----KALLDASETTSTRKIKEE---EKRVN 271
            .:.:.|..|:.:.|    .|:.::.:..|.:..|     ..||...||..|.|:...   ::|..
  Fly   404 NSDQNLTKVKLQYQ----KAHNELNETHQFFASMLDERKTELLKELETLYTAKVNSNNSWQQRSR 464

Human   272 SKFD------------------TIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLR-GI 317
            ...|                  .:.:.||.:||..|.|:..| |.:....|.||:.....:: |:
  Fly   465 DLIDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQQLQTGI-QEMQLPFEIEFMSNYQSIQAGV 528

Human   318 STKPVYI 324
            .....||
  Fly   529 RNTFGYI 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIM25	NP_005073.2	RING	13..53	CDD:302633	6/23 (26%)
		Interaction with influenza A virus NS1	180..450		40/189 (21%)
		HR1	180..252	CDD:294066	18/93 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..403
		SPRY_PRY_TRIM25	459..627	CDD:293971
brat	NP_001188842.2	BBOX	176..222	CDD:197662	7/48 (15%)
		zf-B_box	328..366	CDD:279037	10/37 (27%)
		NHL_brat_like	760..1030	CDD:271329
		NHL repeat	783..819	CDD:271329
		NHL repeat	830..871	CDD:271329
		NHL repeat	874..910	CDD:271329
		NHL repeat	914..954	CDD:271329
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030