DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRIM25 and trim25

DIOPT Version :9

Sequence 1:	NP_005073.2	Gene:	TRIM25 / 7706	HGNCID:	12932	Length:	630	Species:	Homo sapiens
Sequence 2:	XP_031749815.1	Gene:	trim25 / 100127751	XenbaseID:	XB-GENE-5893541	Length:	638	Species:	Xenopus tropicalis

Alignment Length:	649	Identity:	267/649 - (41%)
Similarity:	378/649 - (58%)	Gaps:	40/649 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAE-LCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETW-AVQGSPYLCPQCRAVYQARPQL 63
            ||: |..|||||:|||||..|..|||.||||||||.||...| |.:...|.||||...:.::|.|
Frog     1 MAQSLDSLAEELTCSICLGLFNTPVTIPCGHNFCGECLELAWEACKLGEYRCPQCMCPFPSKPDL 65

Human    64 HKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVKTCLVCMASFCQ 128
            .|||:|.|:|.|.....|..:.|..|.....:.. |..:..|.||.|:...|.:|||.|||||||
Frog    66 RKNTLLNNLVIQLQSLQLKPQEPEPVLLNVVKED-PCYSDGVLCDSCMALPAARTCLTCMASFCQ 129

Human   129 EHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLVEHKTCSPASLSQ 193
            |||:||.:||||..|.|:.|:|||..|||.:|.:|.:.:|.||..|||..||..||.|...:|.|
Frog   130 EHLRPHLESPAFIHHLLKQPLRDLHARKCQEHEKLLDQYCREHLCCICCYCLANHKQCHTCTLQQ 194

Human   194 ASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETT 258
            ...:.:..:.:.|..:..:|..||....::|..|:.|..|.|:|.:.|:.|:.|:|||::..:..
Frog   195 GKMERKRDISNILQSLNQKIEKASNTAGELRREQKQVMDTVNKKKDLLEGEFEEIKALIEQEKMK 259

Human   259 STRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVY 323
            |.|||:||||:|||||.....:|.|||.|.:.:|..:|..|.:.|:.:||::||||...::|..|
Frog   260 SMRKIEEEEKKVNSKFGYTLSVLGKKKQEFEKMKSSVESLLLEEDDLQFLKRASKLHDTTSKEPY 324

Human   324 IPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPT------------PSSGDPGEHDPASTHKS 376
            .|::||:.||:..|.::|:.||:.:|   .:||:|.            |...|..|..|::.  |
Frog   325 KPKMELDEKLLHQIFRNTVSLKDSIK---AKLQQPDDTVEKMSTGGRHPKQDDTQEWKPSAA--S 384

Human   377 TRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSH-PNSTSLKAKV 440
            |..:....:..|:::.|        ...||.:.....::::...:...:||..| |::|:...|
Frog   385 TERIPAGGRHPKQAETP--------NKNTFASTPTFPEVERHPKKGKPRATGPHVPSATAPDDK- 440

Human   441 LETFLAK---------SRPELLEYYIKVILDYNTAHNKVALSECYTVASVAEMPQNYRPHPQRFT 496
             ...|||         ||.::|:|..:|..|.:|||.:|.|||..|..||:|..|:|..:|:|||
Frog   441 -NKPLAKSKRGPSVPDSREDVLKYVAQVTADPSTAHKRVLLSERNTKVSVSEGAQSYPDNPERFT 504

Human   497 YCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPESRLGRNSASWCVEWFNTKISAW 561
            :|||||....:.:|.|||||::|..||.|.||.|.|:.|:|.|||||||..|||:|:||.|:.||
Frog   505 HCSQVLCSQGFSQGTHYWEVDIQGGNFSGFGIAYRSIPRKGAESRLGRNPVSWCLEYFNGKLQAW 569

Human   562 HNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEALYPAFWVFSAGATLS 625
            |:..|.:|.|....|:|:|||.|.||:.||:|:.|...:|:||..||||:|||||||||.|.:|
Frog   570 HDEKETSLTSPNTNRIGLLLNYDEGFLSFFSVSKKFSQIYRFRAHFTEAVYPAFWVFSANAVVS 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIM25	NP_005073.2	RING	13..53	CDD:302633	24/40 (60%)
		Interaction with influenza A virus NS1	180..450		85/291 (29%)
		HR1	180..252	CDD:294066	21/71 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..403		11/59 (19%)
		SPRY_PRY_TRIM25	459..627	CDD:293971	90/167 (54%)
trim25	XP_031749815.1	RING-HC_TRIM65_C-IV	12..56	CDD:319523	26/43 (60%)
		Bbox1_TRIM25-like_C-IV	107..153	CDD:380900	27/45 (60%)
		Bbox2_TRIM25_C-IV	156..192	CDD:380834	16/35 (46%)
		Smc	<198..>339	CDD:224117	51/140 (36%)
		SPRY	467..633	CDD:413402	89/165 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I12473
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I7845
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114530at33208
OrthoFinder	1	1.000	-	-		FOG0011100
OrthoInspector	1	1.000	-	-		oto155357
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X12
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060