DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB16 and CG31365

DIOPT Version :9

Sequence 1:	NP_001018011.1	Gene:	ZBTB16 / 7704	HGNCID:	12930	Length:	673	Species:	Homo sapiens
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	612	Identity:	142/612 - (23%)
Similarity:	232/612 - (37%)	Gaps:	143/612 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    62 LFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKM----- 121
            :|.::...|..|.|.   |:..:.:   ..:|.|...|:|     |....::.|||..:|
  Fly    99 VFSKDPDDYDEDELE---FEDSIAF---IEVQDKVRKLED-----EKWREDFKEEQAAEMHKRLV 152

Human   122 ---LETIQASDDNDTEATMADGG--------AEEEEDRKARYLKNIFISKHSSEES-----GYAS 170
               || ::|....:....:|:..        |||...:....|:| .:|:...:|.     |...
  Fly   153 KSRLE-LRAKLTTELRKELAEEVRSEVRKELAEEVRSQVRDDLRN-EVSEDIRKEQLAMLLGELE 215

Human   171 V------AG--QSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPA----G 223
            |      ||  :||.|...:..|.|...     .||:::...:|.....||:...|:...    .
  Fly   216 VYLTEKKAGRWESLDGSEPETKPQVKED-----ASPSRSKTKALPKRRPSLVDANLKATEARKDA 275

Human   224 PEEPTLAGGGRHP-GVAEVKTEMMQVD-EVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRS 286
            .||..:.|....| ..::|..:.:::| |||::......|.::.|                   |
  Fly   276 KEEEFILGCNTDPANNSDVNIDGLELDEEVPAESGEDFREINMVG-------------------S 321

Human   287 SVI-TSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPS 350
            .|: |...|::.....|:|.        |.....||.     ::..||.|.  |.|.|..:.
  Fly   322 DVVHTDNGEIYIINSASSED--------QNQDSTPEF-----DQDNGITSY--NIKEDGEIQ--- 368

Human   351 SVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPD 415
                                :.|..|:. |:..:...|||   .:..|.:......:|..||...
  Fly   369 --------------------FSGEKPEE-IEDVVVFNLGE---EISQEQQVFSFHENVIIVEKEQ 409

Human   416 NEAVEQ---HRKLHSGMKTYGCELCGK----RFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKE 473
            |:..||   .||..|.:.......|.:    |..|::             |:|.|..|...|..:
  Fly   410 NDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTV-------------KSFQCHLCPVAFPTQ 461

Human   474 DALETHRQTH-----TGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTAL 533
            ..|..|..||     :|....:.|..|..:....|:|::||.:|.|::.:.||||..:|.....|
  Fly   462 KLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVL 526

Human   534 KRHLRSHTGDHPYECEFCGSCFRDESTLKSH-KRIHTG-EKPYECNGCGKKFSLKHQLETHYRVH 596
            |||:.:|||...::|..|.|||..:|.|:.| .|:|.| .:.::|:.|.:.|:....|..|...|
  Fly   527 KRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTH 591

Human   597 TGEKPFECKLCHQRSRDYSAMIKHLRT 623
            .|.. |.||.|.::..|.||:.:|:.|
  Fly   592 AGVM-FSCKQCGRQFNDRSAVQRHVTT 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB16	NP_001018011.1	BTB	25..125	CDD:306997	16/70 (23%)
		Herpes_ICP4_C	177..>327	CDD:332854	29/156 (19%)
		Interaction with RUNX1T1. /evidence=ECO:0000269\|PubMed:10688654	200..300		19/106 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..236		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..332		15/84 (18%)
		C2H2 Zn finger	406..426	CDD:275368	8/22 (36%)
		C2H2 Zn finger	434..454	CDD:275368	3/23 (13%)
		COG5048	<448..622	CDD:227381	56/180 (31%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	9/19 (47%)
		C2H2 Zn finger	548..568	CDD:275368	9/20 (45%)
		C2H2 Zn finger	576..596	CDD:275368	5/19 (26%)
		C2H2 Zn finger	604..624	CDD:275368	8/20 (40%)
		C2H2 Zn finger	632..652	CDD:275368
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	32/152 (21%)
		RRF	<161..222	CDD:294170	10/61 (16%)
		zf-C2H2_8	454..530	CDD:292531	23/75 (31%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	10/24 (42%)
		C2H2 Zn finger	513..533	CDD:275368	9/19 (47%)
		zf-H2C2_2	526..550	CDD:290200	12/23 (52%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..617	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910