DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZBTB16 and CG14655

DIOPT Version :9

Sequence 1:NP_001018011.1 Gene:ZBTB16 / 7704 HGNCID:12930 Length:673 Species:Homo sapiens
Sequence 2:NP_649494.1 Gene:CG14655 / 40594 FlyBaseID:FBgn0037275 Length:525 Species:Drosophila melanogaster


Alignment Length:517 Identity:116/517 - (22%)
Similarity:175/517 - (33%) Gaps:178/517 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   198 PTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVP----SQDSPG 258
            |:..::|:|.   |.|::....|.|.|             .|..|...:.:|::.    |..|..
  Fly    14 PSFGSIDALQ---QRLIKAANGPLACP-------------FANCKELFLGLDKLTIHLFSHTSLM 62

Human   259 AAESSISGGMGDKVEERGKEGP--GTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPE 321
            |.|              |.|.|  |.|..|....:|              .||....:....:|.
  Fly    63 AQE--------------GNESPANGQPASSRGFLAA--------------APPKRRAKRTRSKPV 99

Human   322 HPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFS 386
            .|.|||     :.:..|.|......|..::....:||:                           
  Fly   100 VPTPPP-----VRTTPPAHCDICEFSFRNTELRDMHVR--------------------------- 132

Human   387 KLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHL 451
            .:.|.|.|...:.....::        ||.|             .|.|.||.|.|.....||:||
  Fly   133 LVHENAEGEPKQKEPQQKE--------PDQE-------------PYKCHLCSKTFRMKGSLRIHL 176

Human   452 -LAHSAGA--------------------------KAFVCDQ----------------CGAQ--FS 471
             :.|..|.                          |..:||:                |.|.  ::
  Fly   177 KVVHMMGVPCSNPNPNPNPSPTPASTTSAVTATPKLSICDRIRHTEPGALGNGNNSTCTASQPYA 241

Human   472 KEDALETHRQ------THTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSH 530
            ...||...:|      :.|.|.....|.:|.|.|..:..|::|..:|.|...|.|..|.|||...
  Fly   242 LSGALSMLQQSPSSPESGTATPKLWECDVCSKSFTTKYFLKKHKRLHTGEMPYTCEICARTFTFQ 306

Human   531 TALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRV 595
            .:..:||..|:...|:.|..||..|::.|||.:|:|||:||||::|..|||.|..:.....|.|:
  Fly   307 QSYHKHLLYHSEVKPHVCGVCGRAFKELSTLHNHQRIHSGEKPFKCEVCGKCFRQRVSFLVHTRI 371

Human   596 HTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEI 657
            |||..|::|:||.:..|                 |:.:..|..||:       .:...||::
  Fly   372 HTGVMPYKCELCQKTFR-----------------YKVSQRTHRCPT-------EEAQTPEQL 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZBTB16NP_001018011.1 BTB 25..125 CDD:306997
Herpes_ICP4_C 177..>327 CDD:332854 27/134 (20%)
Interaction with RUNX1T1. /evidence=ECO:0000269|PubMed:10688654 200..300 21/105 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 215..236 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 249..332 19/88 (22%)
C2H2 Zn finger 406..426 CDD:275368 3/19 (16%)
C2H2 Zn finger 434..454 CDD:275368 9/20 (45%)
COG5048 <448..622 CDD:227381 63/224 (28%)
C2H2 Zn finger 463..483 CDD:275368 7/43 (16%)
C2H2 Zn finger 492..512 CDD:275368 6/19 (32%)
C2H2 Zn finger 520..540 CDD:275368 7/19 (37%)
C2H2 Zn finger 548..568 CDD:275368 9/19 (47%)
C2H2 Zn finger 576..596 CDD:275368 7/19 (37%)
C2H2 Zn finger 604..624 CDD:275368 4/19 (21%)
C2H2 Zn finger 632..652 CDD:275368 3/19 (16%)
CG14655NP_649494.1 C2H2 Zn finger 268..288 CDD:275368 6/19 (32%)
zf-H2C2_2 281..304 CDD:290200 9/22 (41%)
C2H2 Zn finger 324..344 CDD:275368 9/19 (47%)
zf-H2C2_2 339..361 CDD:290200 13/21 (62%)
C2H2 Zn finger 352..372 CDD:275368 7/19 (37%)
zf-H2C2_2 364..389 CDD:290200 10/41 (24%)
C2H2 Zn finger 380..396 CDD:275368 5/32 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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