DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PCGF2 and l(3)73Ah

DIOPT Version :9

Sequence 1:	NP_001356543.1	Gene:	PCGF2 / 7703	HGNCID:	12929	Length:	344	Species:	Homo sapiens
Sequence 2:	NP_001246797.1	Gene:	l(3)73Ah / 48903	FlyBaseID:	FBgn0002283	Length:	222	Species:	Drosophila melanogaster

Alignment Length:	233	Identity:	89/233 - (38%)
Similarity:	139/233 - (59%)	Gaps:	29/233 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     6 RIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIR 70
            |:|:..:|||:.|.:||||||||||:.||||:|||:|:|::||..|.||.||..:|::.||..|.
  Fly     4 RVKLKTINPHITCKICGGYFIDATTVTECLHTFCKSCLVKHLEEKKTCPTCDNIIHQSHPLQYIS 68

Human    71 SDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL---TEVPNGSNEDRGEVLEQEKGALSD----D 128
            .|:|:|||||||||.|.:||.:|.||||.:..:   .::.....:|..:|::..  |.||    |
  Fly    69 FDRTMQDIVYKLVPKLQEDESRRERDFYKSRNMPCPKDITQNHEDDNEKVMDAH--AESDFHRLD 131

Human   129 EIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNK-MDVPSKYK 192
            |.|::.:|.             :.|...:.::   ||:||.:..|:.||.|.:..| ::...||:
  Fly   132 EQVNVCLEC-------------ISNNFKNLQR---RFIRCSSQATITHLKKLVAKKILNGIEKYR 180

Human   193 -VEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYR 228
             :::|..:|.|.:.:|| ...|:..|| |:.||.|::|
  Fly   181 EIDILCNEELLGKDHTL-KFVYVTRWRFRDPPLRLQFR 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCGF2	NP_001356543.1	RING-HC_PCGF4	12..65	CDD:319650	31/52 (60%)
		RING-HC finger (C3HC4-type)	18..56	CDD:319650	25/37 (68%)
		Nuclear localization signal. /evidence=ECO:0000255	81..95		8/13 (62%)
		RAWUL_PCGF2	130..228	CDD:340684	26/100 (26%)
		PLN02217	<236..328	CDD:215130
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..344
l(3)73Ah	NP_001246797.1	RING-HC_PCGF3	13..59	CDD:319649	28/45 (62%)
l(3)73Ah	NP_001246797.1	RAWUL_PCGF3	133..217	CDD:340603	26/100 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810