DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF143 and Kr-h1

DIOPT Version :9

Sequence 1:	XP_005253178.1	Gene:	ZNF143 / 7702	HGNCID:	12928	Length:	653	Species:	Homo sapiens
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	172/703 - (24%)
Similarity:	248/703 - (35%)	Gaps:	182/703 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    12 FSEKMLLAQINRDSQ------------------GMTEFPGGGMEAQHVTLCLTE-----AVTVAD 53
            :|...||.:..:.||                  |:...|.||.: :|..|..|.     .:.:.|
  Fly    58 YSANQLLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVPPSGGQQ-EHFELLQTPQQRQMQLQLQD 121

Human    54 GDNLENMEGVSLQ-AVTLADGSTAYIQH----NSKDAKLIDGQVIQLE-----DGSAAYVQHVPI 108
            ....|..:.||.| |:..........||    |:........|.|:.|     ..|||.|..|..
  Fly   122 QHQQEQQQFVSYQLAIQQHQKQQQQQQHESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRK 186

Human   109 PKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSALQAVQLEDGTTAYIHHAVQVPQSDTIL 173
            |.::....:.:  |........:|...||...|.:|.    :.|...:.|    .|..|.|...:
  Fly   187 PSASKPQFKCD--QCGMTFGSKSAHTSHTKSHSKNQD----LSLNGASGA----GVAAPVSTAAI 241

Human   174 AIQADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSESVAGTGMIGENEQEKKMQIVLQGHAT 238
            .:...|...|:...      .||..|...||
  Fly   242 ELNDAGLPVGIPKS------PTIKPLANVAA---------------------------------- 266

Human   239 RVTAKSQQSGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHV 303
                     |...::|..  |.|.:.....|..|.|:|||:||::||.  |.|.|:....|:.|.
  Fly   267 ---------GADPYQCNV--CQKTFAVPARLIRHYRTHTGERPFECEF--CHKLFSVKENLQVHR 318

Human   304 RTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTG 368
            |.||.|:||:|  |.|.::|:.||.|.:|:|.||||||.||..  |.::|..|....:|:|||||
  Fly   319 RIHTKERPYKC--DVCGRAFEHSGKLHRHMRIHTGERPHKCSV--CEKTFIQSGQLVIHMRTHTG 379

Human   369 ERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYN 433
            |:||.|.|||||:.|..:...|.|.|.|||||||.|.:  |.:.|.....|..|.|.|..||.|.
  Fly   380 EKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDI--CFRDFGYNHVLKLHRVQHYGSKCYK 442

Human   434 CNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGEDVLKGSQITYVTGVEGDDVVS 498
            |..|.:|:|....:..|.: .|.:..|.:|.:.|                              :
  Fly   443 CTICDETFKNKKEMEAHIK-GHANEVPDDEAEAA------------------------------A 476

Human   499 TQVATVTQSGLS------QQVTLISQDGTQHVNIS--------QADMQAIGNTITMVTQDGTPIT 549
            ...|..|.:|.|      |.|:..|:........|        ||....:..|:....  ..|.:
  Fly   477 ASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATL--SIPTS 539

Human   550 VPAHDAVISSAGTHSV-AMVTAEGTEGEQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTETRPLT 613
            .|...:.:||..:.|. :|.:...|....:.:..:..|....:........||.:   .:..|..
  Fly   540 SPLSPSSLSSTYSPSASSMASPPPTSAHYLPVQMEADALSRDSGVSSAQPAHSTY---ADEEPTD 601

Human   614 LVATSNGTQIAVQLGE------------------------QPSLEEAIRIASR 642
            |    :..|:..||.|                        .|:|.||..||.|
  Fly   602 L----SMQQVQGQLPESTVDYYQAPPSLLELQPQPAGLTINPALLEAASIARR 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF143	XP_005253178.1	Trp-synth-beta_II	<97..207	CDD:294246	24/109 (22%)
		C2H2 Zn finger	254..276	CDD:275368	6/21 (29%)
		zf-H2C2_2	268..295	CDD:290200	13/26 (50%)
		COG5048	279..>337	CDD:227381	24/57 (42%)
		C2H2 Zn finger	284..306	CDD:275368	8/21 (38%)
		zf-H2C2_2	299..325	CDD:290200	12/25 (48%)
		zf-C2H2_8	314..429	CDD:292531	53/114 (46%)
		C2H2 Zn finger	314..336	CDD:275368	9/21 (43%)
		zf-H2C2_2	328..355	CDD:290200	13/26 (50%)
		C2H2 Zn finger	344..366	CDD:275368	6/21 (29%)
		zf-H2C2_2	360..385	CDD:290200	16/24 (67%)
		C2H2 Zn finger	374..396	CDD:275368	10/21 (48%)
		zf-H2C2_2	388..414	CDD:290200	12/25 (48%)
		C2H2 Zn finger	404..426	CDD:275368	6/21 (29%)
		C2H2 Zn finger	434..453	CDD:275368	5/18 (28%)
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	4/21 (19%)
		COG5048	<270..420	CDD:227381	72/159 (45%)
		zf-C2H2	271..293	CDD:278523	6/23 (26%)
		C2H2 Zn finger	273..293	CDD:275368	6/21 (29%)
		zf-H2C2_2	286..309	CDD:290200	12/24 (50%)
		C2H2 Zn finger	301..321	CDD:275368	8/21 (38%)
		zf-H2C2_2	313..338	CDD:290200	12/26 (46%)
		C2H2 Zn finger	329..349	CDD:275368	9/21 (43%)
		zf-H2C2_2	344..366	CDD:290200	12/23 (52%)
		C2H2 Zn finger	357..377	CDD:275368	6/21 (29%)
		zf-H2C2_2	370..396	CDD:290200	16/25 (64%)
		C2H2 Zn finger	385..407	CDD:275368	10/21 (48%)
		zf-H2C2_2	400..424	CDD:290200	13/25 (52%)
		C2H2 Zn finger	415..435	CDD:275368	6/21 (29%)
		zf-C2H2	441..463	CDD:278523	6/22 (27%)
		C2H2 Zn finger	443..463	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910