DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF132 and CG18262

DIOPT Version :9

Sequence 1:	NP_003424.3	Gene:	ZNF132 / 7691	HGNCID:	12916	Length:	706	Species:	Homo sapiens
Sequence 2:	NP_572453.1	Gene:	CG18262 / 31745	FlyBaseID:	FBgn0030012	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	122/483 - (25%)
Similarity:	192/483 - (39%)	Gaps:	106/483 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    78 GSWHGVE-GE---GAHPKQNVSVEVLQVRIP-NADPSTKKA-----NSCDMCG------PFLKDI 126
            |.:|.:. ||   .|.....||..:...|:| :..|...:.     :|..:|.      |..:|:
  Fly    12 GGYHNLRCGEVLFSAPASYEVSCLLCDQRLPLDGYPEHFRLKHFTNSSSSLCSNELESDPIAQDV 76

Human   127 LHLAE----HQGTQSEEKPYTCGACGRDFWLNANLHQHQKEHSGGKPFRWYKDRDALMKSSKVHL 187
            :.:..    |:....|..|              :|.:.::|...|...:.|: |.|.||::.|..
  Fly    77 VEVQGNEELHEELAKEASP--------------DLEEEEEEKEEGSKRQHYQ-RAAAMKNTLVET 126

Human   188 SENPFTCREGGKVILGSCDLLQLQAVDSGQKPYSNLGQLPEVCTTQKLFECSNCGKAFLKSSTLP 252
            .|                |||.::...:|       |:..|
  Fly   127 RE----------------DLLDIELDWTG-------GEQSE------------------------ 144

Human   253 NHLRTHSEEIPFTCPTGGNFLEEKSILGNKKFHTGEIPHVCKECGKAFSHSSKLRKHQKF-HTEV 316
             |..||.||       .|...::.:...|   .|.::...|.:|.:|::....|:.|::. |:|
  Fly   145 -HNETHEEE-------EGESDDDDTKDSN---DTKDMLFQCDQCDRAYNTKRSLQSHRRLKHSE- 197

Human   317 KYYECIACGKTFNHKLTFVHHQRIHSGERPYECDE--CGKAFSNRSHLIRHEKVHTGERPFECLK 379
                  |.|.:.:...:..:.::.....:.|:|:|  |.:.|.....|..|...|||   ..|..
  Fly   198 ------ANGGSLDKSASERNSKKRKGPPKVYKCNEEACNQTFRTERDLRGHRWKHTG---IFCDI 253

Human   380 CGRAFSQSSNFLRHQKVHTQVRPYECSQCGKSFSRSSALIQHWRVHTGERPYECSECGRAFNNNS 444
            ||:.|:||.|.:||::.|:.::|::|.:|..:|.....|..|...|||..|..|..|||...:..
  Fly   254 CGKPFTQSGNMMRHRQRHSGIKPHKCPECDATFYTQKELSSHSICHTGRMPCICEVCGRPCRDRG 318

Human   445 NLAQHQKVHTGERPFECSECGRDFSQSSHLLRHQKVHTGERPFECCDCGKAFSNSSTLIQHQKVH 509
            .|..|.:.||||||.:|..||:.|.....|..|...||..|||.|..||..|.....|..|:.:|
  Fly   319 VLTAHMRRHTGERPAKCEVCGKAFYSFHDLNVHAVSHTNLRPFVCDVCGSTFQRKKALRVHKLLH 383

Human   510 TGQRPYECSECRKSFSRSSSLIQHWRIH 537
            :.||.|.|..|.|:|::|..|..|.|.|
  Fly   384 SEQRKYACKLCGKTFAQSGGLNAHMRSH 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF132	NP_003424.3	KRAB	37..78	CDD:307490	122/483 (25%)
		COG5048	105..528	CDD:227381	108/440 (25%)
		C2H2 Zn finger	116..136	CDD:275368	4/29 (14%)
		C2H2 Zn finger	144..164	CDD:275368	1/19 (5%)
		C2H2 Zn finger	238..285	CDD:275368	7/46 (15%)
		C2H2 Zn finger	293..313	CDD:275368	5/20 (25%)
		C2H2 Zn finger	321..341	CDD:275368	2/19 (11%)
		C2H2 Zn finger	349..369	CDD:275368	6/21 (29%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		COG5048	383..>706	CDD:227381	59/155 (38%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		C2H2 Zn finger	545..565	CDD:275368
		C2H2 Zn finger	573..593	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
CG18262	NP_572453.1	C2H2 Zn finger	224..246	CDD:275368	6/21 (29%)
		C2H2 Zn finger	251..271	CDD:275368	9/19 (47%)
		COG5048	<256..415	CDD:227381	59/156 (38%)
		zf-H2C2_2	263..288	CDD:290200	8/24 (33%)
		C2H2 Zn finger	279..327	CDD:275368	15/47 (32%)
		zf-H2C2_2	320..342	CDD:290200	11/21 (52%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		zf-C2H2	389..411	CDD:278523	9/21 (43%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000