DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF131 and CG6654

DIOPT Version :9

Sequence 1:	NP_001284477.1	Gene:	ZNF131 / 7690	HGNCID:	12915	Length:	623	Species:	Homo sapiens
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	129/562 - (22%)
Similarity:	203/562 - (36%)	Gaps:	168/562 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    85 LIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEENTT------GKNEAK 143
            ||:.|.:..|..:||.|..|.....|                    |:|:.|:      |..:.:
  Fly   135 LIKSTISVDLDYEGEGEVFDYELPDE--------------------PVEKTTSLILQVQGNLKDE 179

Human   144 KRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVEDEGIE--------TLEEVASAKQSVKYI 200
            |..:...:|||      .|.:..|:|.:|.|..:.: .||::        |..:|.:.|.:.|.:
  Fly   180 KEVVFTQTNVI------YEGDDHELEQQIRECNLAI-FEGVDNEAEIITVTAPQVTTRKSAAKLL 237

Human   201 --------QSTGSSDDSALALLADIT--SKYRQGDRKGQIKED---GCPSD--PTSKQ------- 243
                    |:...|.:.|..|..:..  |..|...|:|.:|:|   ..|||  |:.||
  Fly   238 TQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQR 302

Human   244 ---------VEGIEIVELQLSHVKDLFHCEKCNRSF----KLFYHFKEHMKSHSTESFKCEICNK 295
                     |.|........:..:..:||::||..|    .|..|.::  |.....::||..|.|
  Fly   303 KLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQ--KGCINRNYKCNECEK 365

Human   296 RYLRESAWKQHL------NCYHLEEGGV--------SKKQRTGKKIHV---CQYCEKQFDHFGHF 343
            .::......:|.      ||   .|.|:        ||....|.|.::   |..|:|.|......
  Fly   366 VFVSPDHLAEHQASHGAHNC---PECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTL 427

Human   344 KEHLRKHTGEKPFECPNCHERFARNSTL-------------KCHL------------TACQTGVG 383
            ::|:|.|||||||.|..|.:.|.:|:.|             ||.|            :..:|..|
  Fly   428 RDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTG 492

Human   384 AKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPNHCTLCDLWFMQGNELRRHLSDAHNISER 448
            .|.     :||:||.:.|.:......|...|||::|..|.||.:.|...|.|:.|        .|
  Fly   493 DKP-----FECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNH--------RR 544

Human   449 LVTEEVLSVETRVQTEPVTSMTIIE-----------QVGKVHVLPLLQVQVDSAQVTVEQVHPDL 502
            ..|.|      |....|..|.|..:           |..::::.|:...:..|.        |::
  Fly   545 THTGE------RPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSM--------PEM 595

Human   503 LQDSQVHDSHMSELPEQVQVSYLEVGRIQTEEGTEVHVEELH 544
            ......|:.|...|   |..::|.    ..|.|:....|||:
  Fly   596 RSHLAGHEQHDKRL---VHFTFLS----NKENGSGALEEELN 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF131	NP_001284477.1	BTB	24..122	CDD:279045	9/36 (25%)
		BTB	35..122	CDD:197585	9/36 (25%)
		Nuclear localization signal 1. /evidence=ECO:0000269\|PubMed:17306895	137..148		2/16 (13%)
		COG5048	<262..444	CDD:227381	62/227 (27%)
		C2H2 Zn finger	263..283	CDD:275368	7/23 (30%)
		C2H2 Zn finger	290..311	CDD:275368	6/26 (23%)
		Nuclear localization signal 2. /evidence=ECO:0000269\|PubMed:17306895	317..328		4/18 (22%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..367	CDD:290200	12/24 (50%)
		C2H2 Zn finger	358..375	CDD:275368	7/29 (24%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	422..439	CDD:275370	6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..623
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/24 (29%)
		COG5048	<357..570	CDD:227381	61/234 (26%)
		C2H2 Zn finger	360..380	CDD:275368	4/19 (21%)
		C2H2 Zn finger	385..406	CDD:275370	5/23 (22%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	8/47 (17%)
		C2H2 Zn finger	470..487	CDD:275368	2/16 (13%)
		zf-H2C2_2	482..507	CDD:290200	8/29 (28%)
		C2H2 Zn finger	498..518	CDD:275368	5/19 (26%)
		zf-H2C2_2	510..534	CDD:290200	8/23 (35%)
		C2H2 Zn finger	526..546	CDD:275368	8/27 (30%)
		zf-H2C2_2	539..563	CDD:290200	9/37 (24%)
		C2H2 Zn finger	554..574	CDD:275368	3/19 (16%)
		C2H2 Zn finger	582..602	CDD:275368	3/27 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000