DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF131 and Kr

DIOPT Version :9

Sequence 1:NP_001284477.1 Gene:ZNF131 / 7690 HGNCID:12915 Length:623 Species:Homo sapiens
Sequence 2:NP_001261181.1 Gene:Kr / 38012 FlyBaseID:FBgn0001325 Length:502 Species:Drosophila melanogaster


Alignment Length:345 Identity:76/345 - (22%)
Similarity:136/345 - (39%) Gaps:92/345 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   286 ESFKCEICNKRYLRESAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCEKQFDHFGHFKEHLRKH 350
            :||.|:||::.:..:...:.|            ::..||:|...|..|.|:|....|.|.|:|.|
  Fly   220 KSFTCKICSRSFGYKHVLQNH------------ERTHTGEKPFECPECHKRFTRDHHLKTHMRLH 272

Human   351 TGEKPFECPNCHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHT 415
            |||||:.|.:|..:|.:.:.|:.||.. .||       ::.|.|::|:..|:..:|.|.|:::|.
  Fly   273 TGEKPYHCSHCDRQFVQVANLRRHLRV-HTG-------ERPYTCEICDGKFSDSNQLKSHMLVHN 329

Human   416 GDKPNHCTLCDLWFMQGNELRRHLSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHV 480
            |:||..|..|.:.|.:.:.|..|                   :..:|:.|..:::..........
  Fly   330 GEKPFECERCHMKFRRRHHLMNH-------------------KCGIQSPPTPALSPAMSGDYPVA 375

Human   481 LPLLQVQ-------------------VDSAQVTVEQVHP-DLLQD--SQVHDSHMSELPEQVQVS 523
            :..:.::                   ||..:.|.|...| ||.:|  |.| |.|.|         
  Fly   376 ISAIAIEASTNRFAAMCATYGGSNESVDMEKATPEDDGPLDLSEDGASSV-DGHCS--------- 430

Human   524 YLEVGRIQTEEGTEVHVEELHVERVNQMPVEVQTELLEADLDHVTPEIMNQEERESSQADAAEAA 588
              .:.|.:.::          :.||.::|        ...:.||..::..|.|.|.....:..:.
  Fly   431 --NIARRKAQD----------IRRVFRLP--------PPQIPHVPSDMPEQTEPEDLSMHSPRSI 475

Human   589 REDHEDAEDLETKPTVDSEA 608
             ..||..:|::.....|:.|
  Fly   476 -GSHEQTDDIDLYDLDDAPA 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF131NP_001284477.1 BTB 24..122 CDD:279045
BTB 35..122 CDD:197585
Nuclear localization signal 1. /evidence=ECO:0000269|PubMed:17306895 137..148
COG5048 <262..444 CDD:227381 47/157 (30%)
C2H2 Zn finger 263..283 CDD:275368
C2H2 Zn finger 290..311 CDD:275368 4/20 (20%)
Nuclear localization signal 2. /evidence=ECO:0000269|PubMed:17306895 317..328 3/10 (30%)
C2H2 Zn finger 330..350 CDD:275368 8/19 (42%)
zf-H2C2_2 342..367 CDD:290200 13/24 (54%)
C2H2 Zn finger 358..375 CDD:275368 4/16 (25%)
C2H2 Zn finger 394..414 CDD:275368 6/19 (32%)
C2H2 Zn finger 422..439 CDD:275370 4/16 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 573..623 8/36 (22%)
KrNP_001261181.1 C2H2 Zn finger 224..244 CDD:275368 4/31 (13%)
zf-H2C2_2 237..261 CDD:290200 8/35 (23%)
C2H2 Zn finger 252..272 CDD:275368 8/19 (42%)
zf-H2C2_2 264..289 CDD:290200 13/24 (54%)
C2H2 Zn finger 280..300 CDD:275368 6/20 (30%)
zf-H2C2_2 292..316 CDD:290200 8/31 (26%)
C2H2 Zn finger 308..328 CDD:275368 6/19 (32%)
zf-H2C2_2 321..345 CDD:290200 9/23 (39%)
C2H2 Zn finger 336..352 CDD:275368 4/15 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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