DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF131 and kel-20

DIOPT Version :9

Sequence 1:	NP_001284477.1	Gene:	ZNF131 / 7690	HGNCID:	12915	Length:	623	Species:	Homo sapiens
Sequence 2:	NP_491322.2	Gene:	kel-20 / 172012	WormBaseID:	WBGene00020030	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	178	Identity:	44/178 - (24%)
Similarity:	69/178 - (38%)	Gaps:	36/178 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    20 ILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE-----FTQEPLVEIEGVSK 79
            :|.:|...:.:|...|:|||.......||:.||:|||.:|...|..     :.:|  :.:|.:..
Worm    42 VLQQLGGLKNRDVLCDVTLICGWKRINAHRVVLSACSPYFLSMFTSQMAECYMRE--INMEEIEP 104

Human    80 MAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEA--------IKALEVRN----------- 125
            .....||||.||..:.|. :....|:..||..||:.|.        .|.|:..|
Worm   105 PTLEALIEFCYTGAIAID-DSNVQDILPAACLLQIHEVQTACCDYLKKQLDPSNCLGIRAFADTH 168

Human   126 --KENSAPLEE-------NTTGKNEAKKRKIAETSNVITESLPSAESE 164
              ||..:..:|       ...||.|.:...:...:.:|.....:|.||
Worm   169 SCKELLSSADEFALKNFSRVIGKEEFQMLTVESLTTIIKSDKLNAASE 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF131	NP_001284477.1	BTB	24..122	CDD:279045	31/110 (28%)
		BTB	35..122	CDD:197585	29/99 (29%)
		Nuclear localization signal 1. /evidence=ECO:0000269\|PubMed:17306895	137..148		3/10 (30%)
		COG5048	<262..444	CDD:227381
		C2H2 Zn finger	263..283	CDD:275368
		C2H2 Zn finger	290..311	CDD:275368
		Nuclear localization signal 2. /evidence=ECO:0000269\|PubMed:17306895	317..328
		C2H2 Zn finger	330..350	CDD:275368
		zf-H2C2_2	342..367	CDD:290200
		C2H2 Zn finger	358..375	CDD:275368
		C2H2 Zn finger	394..414	CDD:275368
		C2H2 Zn finger	422..439	CDD:275370
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..623
kel-20	NP_491322.2	PHA03098	56..572	CDD:222983	41/164 (25%)
		KELCH repeat	345..389	CDD:276965
		KELCH repeat	393..437	CDD:276965
		KELCH repeat	440..485	CDD:276965
		KELCH repeat	487..531	CDD:276965
		KELCH repeat	534..577	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910