DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mark3b and par-1

DIOPT Version :9

Sequence 1:	XP_009293196.1	Gene:	mark3b / 767634	ZFINID:	ZDB-GENE-060929-80	Length:	834	Species:	Danio rerio
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	894	Identity:	448/894 - (50%)
Similarity:	552/894 - (61%)	Gaps:	174/894 - (19%)

- Green bases have known domain annotations that are detailed below.

Zfish     2 SCQHH---KNGPTV------SFNAIQIANARMKGSH----------SVKRHRITIHTSHTDG-RN 46
            |.|||   .|..|.      |.|:..:|::.:...|          :|.::.::.|::|... :.
  Fly   158 SHQHHHHVANNMTTDGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQ 222

Zfish    47 EVASRPGRSGARCRNS--IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK 109
            ..:|..|....:.|:|  :...|.|: |||.|:|:||||||||||||||:|:.||:|||||||||
  Fly   223 RTSSAKGSPNMQMRSSAPMRWRATEE-HIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDK 286

Zfish   110 TQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKE 174
            |||||.|||||||||||||:|:||||||||:||||:|||||:||||||||||||||.||||||||
  Fly   287 TQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKE 351

Zfish   175 ARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYA 239
            ||.|||||||||||||||.|:||||||||||||:::||||||||||||||.|:||||||||||||
  Fly   352 ARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYA 416

Zfish   240 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 304
            ||||||||||||||||||||||||||||||||||||..|:|||||||||||||||||||||||||
  Fly   417 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLL 481

Zfish   305 KRFLVLNPVKRGTLEQIMKDRWINAGCEEEELKPFVEPELDISDQKRIDIMVGMGYSREEIHESL 369
            ::||||||.||.:||.||.|:|:|.|.||:||||::||:.|::|.|||:.:|.|||:|.||..||
  Fly   482 RKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASL 546

Zfish   370 TRMKYDEITATYLLLGRKSTELEVSDSSSSSNLSLAKARPNSEHNNG-----QSPSHLKVQK--N 427
            ::::||::.|||||||||||:.|...|.|.|:|||.....|....|.     |||:|..|.:  :
  Fly   547 SQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSIS 611

Zfish   428 ASTNQKQRRYSDQAGPTIPSVGYPKRSQTTSAESEHKEEGSAQARKSSSSGSRGMAPASPMLGNA 492
            ||:.:..||.|...|||                       :|.|..::::|:.|
  Fly   612 ASSTKPSRRASSGVGPT-----------------------NAAATVAAATGAVG----------- 642

Zfish   493 NNPNKADIPDRKKSAGAPGNNSVSSGMTRRNTYVCSERNATDRHSVIQNGKENSLSEMSGCVSTS 557
                          |..|.||..::|            :|.||.||..|.|..:
  Fly   643 --------------AVNPSNNYNAAG------------SAADRASVGSNFKRQN----------- 670

Zfish   558 PTAYAVALASSSASVRLRHQKAASLSASGHTCRATL---PTSDASADLFRP---NTSTAQTSQRN 616
             |..:..:..::|.:..::|:.||.:....|...|.   |....:|..:.|   |.:.:.||...
  Fly   671 -TIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGII 734

Zfish   617 PGSST--HSISSATPP-----------DRLR----------FPRGTLSRSTFHGGQLRERRTAT- 657
            |..||  :..:|:|..           ||||          |||...||||||.||.|.|....
  Fly   735 PRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTAL 799

Zfish   658 -YNGPP-ASPTLSHDATPLSQSRSRGSTNLFTKLTSKLTRRNMSFRFSKRVPAECDRNGRYDDSS 720
             |:|.. ||...||.          |..:.|:||:|         ||||| |...|
  Fly   800 EYSGTSGASGDSSHP----------GRMSFFSKLSS---------RFSKR-PTIAD--------- 835

Zfish   721 RNVSGDQKEEHKDAKPRSLRFTWSMKTTSSMEPTEMMREIRKVLDANNCDYEQRERFLLLCVHGD 785
                       :.||||.|||||||||||.:.|.::|::||:|||.|||||||||||:|.|||||
  Fly   836 -----------EAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGD 889

Zfish   786 GHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 834
            .:.:||||||:|||||||||||||||||||||||.||||||:||.:|||
  Fly   890 PNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mark3b	XP_009293196.1	STKc_MARK	75..327	CDD:270974	218/251 (87%)
		S_TKc	76..327	CDD:214567	218/250 (87%)
		UBA_MARK3_4	345..387	CDD:270590	23/41 (56%)
		MARK1-3_C	735..832	CDD:213381	75/96 (78%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	218/251 (87%)
		S_TKc	253..504	CDD:214567	218/250 (87%)
		UBA_MARK_Par1	525..563	CDD:270522	21/37 (57%)
		MARK1-3_C	839..936	CDD:213381	75/96 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	459	1.000	Domainoid score	I467
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55653
Inparanoid	1	1.050	743	1.000	Inparanoid score	I569
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm25828
orthoMCL	1	0.900	-	-		OOG6_101232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.750