DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF99 and CG11247

DIOPT Version :9

Sequence 1:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	360	Identity:	116/360 - (32%)
Similarity:	172/360 - (47%)	Gaps:	50/360 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   329 RKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTEEKPYKYEECGKAFSNLSALRKH-EIIHT 392
            |||.:         |.:|.|.|...:.|::|.:||::|:|:|.::|||::.....|:.| ...|.
  Fly    90 RKHHV---------CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHE 145

Human   393 GQKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKRFSALRKHKIIH--TGKQPYKC 455
            .:|.:.|.:|.|:|....:|.:|..:|:.|||..|:.|.|.|.|...|::|.:.|  |..|.:.|
  Fly   146 HRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNC 210

Human   456 EECSKAFSNFSALRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHMEEKPCKCEECGKAFKH 520
            .:||.:||..:.||.|...|.....::|..|...|  :::|.:...|:.|.
  Fly   211 TKCSASFSTNANLRVHMERHEQGMEHRCSICENQF--ANELALRAHINQEH-------------- 259

Human   521 FSALRKHKIIHTGKKPYKCEECGKAFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKA 585
                  ||:..     ::||.|.|.......|..|...||..|.:.||.|...|.|.|....|..
  Fly   260 ------HKLTQ-----FECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMR 313

Human   586 IHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGK--AFSQSSTLRKH-EIIHTGEK 647
            :||||:||:|..|.:.|.|.|.|:.|...|||:||::|:.|..  ||||.:.|:.| :.||..:|
  Fly   314 MHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQK 378

Human   648 PYKCEECGKAFKWSSHLTRHKVIHTEEKPYKCEEC 682
            ||.||.|...||....|..| |.|       |.:|
  Fly   379 PYMCEGCHDFFKIKVELQSH-VEH-------CAKC 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	267..684	CDD:227381	116/360 (32%)
		zf-H2C2_2	272..296	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368	3/5 (60%)
		zf-H2C2_2	327..352	CDD:290200	7/22 (32%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	5/20 (25%)
		zf-H2C2_2	383..407	CDD:290200	7/24 (29%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		zf-H2C2_2	467..491	CDD:290200	6/23 (26%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		C2H2 Zn finger	511..531	CDD:275368	2/19 (11%)
		zf-H2C2_2	523..548	CDD:290200	6/24 (25%)
		COG5048	534..857	CDD:227381	58/152 (38%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	552..576	CDD:290200	9/23 (39%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		zf-H2C2_2	579..604	CDD:290200	10/24 (42%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		zf-H2C2_2	607..632	CDD:290200	11/26 (42%)
		C2H2 Zn finger	623..643	CDD:275368	8/22 (36%)
		zf-H2C2_2	636..659	CDD:290200	10/23 (43%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		zf-H2C2_2	663..688	CDD:290200	6/20 (30%)
		C2H2 Zn finger	679..699	CDD:275368	2/4 (50%)
		zf-H2C2_2	691..716	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	720..743	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/167 (32%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	5/20 (25%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	10/23 (43%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	63/203 (31%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	6/43 (14%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000