DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CA6 and CAH1

DIOPT Version :9

Sequence 1:XP_011540386.1 Gene:CA6 / 765 HGNCID:1380 Length:324 Species:Homo sapiens
Sequence 2:NP_523561.1 Gene:CAH1 / 34786 FlyBaseID:FBgn0027844 Length:270 Species:Drosophila melanogaster


Alignment Length:283 Identity:91/283 - (32%)
Similarity:142/283 - (50%) Gaps:27/283 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    27 WTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTV 91
            |.|:| ....|||.:.||...|.||||:::..:..:....|....:...........:||.|:..
  Fly     5 WGYTE-ENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSLVNPGYCW 68

Human    92 QISL---PSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYN-SKYKS 152
            ::.:   .|.:........::..:|.|.|||...|:  ||||||||:.:..|:|:||:| :||||
  Fly    69 RVDVNGADSELTGGPLGDQIFKLEQFHCHWGCTDSK--GSEHTVDGVSYSGELHLVHWNTTKYKS 131

Human   153 YDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTL-TGLDVQDMLPRNLQHY 216
            :..|..||||||||..|::..|:  :.......|.|..:.:.|.|.|| .|.|...:|| ::..|
  Fly   132 FGEAAAAPDGLAVLGVFLKAGNH--HAELDKVTSLLQFVLHKGDRVTLPQGCDPGQLLP-DVHTY 193

Human   217 YTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLEN-SLLDHRNKTIHNDYRRTQPLNHRVVES 280
            :||.||||||||:|:|.|.|....:::|..|:..:.| :..|.:.:...|::      |.:|:.:
  Fly   194 WTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEF------NGKVINN 252

Human   281 NFPNQENAYIPSGKGH----GGH 299
            ..|.     :|.||..    |||
  Fly   253 FRPP-----LPLGKRELREIGGH 270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CA6XP_011540386.1 alpha_CA_VI 35..283 CDD:239399 81/253 (32%)
CAH1NP_523561.1 Carb_anhydrase 5..263 CDD:215000 88/274 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3338
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1377476at2759
OrthoFinder 1 1.000 - - FOG0000047
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X57
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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