DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF85 and CG5245

DIOPT Version :9

Sequence 1:	XP_011526565.1	Gene:	ZNF85 / 7639	HGNCID:	13160	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	168/426 - (39%)
Similarity:	234/426 - (54%)	Gaps:	17/426 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   215 KKKP-------FKCTKCGKSFGMISCLTEHSRIHTRVNFYKCEECGKAF----NWSSTLTKHKRI 268
            ||:|       ||||:|.|:|.....|..|.|:|.....::|..|.|:|    ::...|.||::
  Fly    71 KKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEK- 134

Human   269 HTGEKPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKC 333
                :|:||..|.|.|.|:|:|.:|...||||:|:||.:|..:|.|.|.|..|...|:.|:|::|
  Fly   135 ----RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFEC 195

Human   334 KECGKAFNRSSTLTTHRKIHTGEKPYKCEECGKAFKQSSNLTTHKIIHTGEKPYKCKKCGKAFNQ 398
            ..|.|||..:|.|..|.:.|...:|:||..|.|:||..|.|..|.:.| .|:.:||.:|.|.|.|
  Fly   196 THCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQ 259

Human   399 SAHLTTHEVIHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKI 463
            :..|..|..:|.||.|:||..|.:.|...|.|..|.:.|.|::|.||.:|...|...|....|..
  Fly   260 NDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVR 324

Human   464 IHTGEKPYKCKECEKAFNQSSKLTEHKKIHTGEKPYECEKCGKAFNQSSNLTRHKKSHTEEKPYK 528
            :||.|:.|||.||.|:|.:.|.|.||:::||||:|::|..|.|.|...::|..|...|..||..|
  Fly   325 LHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPK 389

Human   529 CEECGKGFKWPSTLTIHKIIHTGEKPYKCEECGKAFNQSSKLTKHKKIHTGEKPYTCEECGKAFN 593
            |..|.|.||..|.|.:|...|||:..::|..|.|::..||.|..|.:.||||.|:.|..|.|.|.
  Fly   390 CSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFA 454

Human   594 QSSNLTKHKRIHTGEKPYKCEECDKAFKWSSVLTKH 629
            :|:...:|.|.|||||||||..|...:...|.|.:|
  Fly   455 RSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF85	XP_011526565.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	189..603	CDD:227381	154/398 (39%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	7/23 (30%)
		zf-H2C2_2	262..286	CDD:290200	9/23 (39%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		zf-H2C2_2	289..314	CDD:290200	11/24 (46%)
		C2H2 Zn finger	305..325	CDD:275368	7/19 (37%)
		zf-H2C2_2	318..342	CDD:290200	10/23 (43%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		zf-H2C2_2	346..370	CDD:290200	9/23 (39%)
		C2H2 Zn finger	361..381	CDD:275368	8/19 (42%)
		zf-H2C2_2	373..398	CDD:290200	9/24 (38%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		zf-H2C2_2	401..426	CDD:290200	10/24 (42%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		zf-H2C2_2	429..454	CDD:290200	9/24 (38%)
		C2H2 Zn finger	445..465	CDD:275368	5/19 (26%)
		zf-H2C2_2	458..482	CDD:290200	11/23 (48%)
		C2H2 Zn finger	473..493	CDD:275368	9/19 (47%)
		zf-H2C2_2	486..510	CDD:290200	12/23 (52%)
		C2H2 Zn finger	501..521	CDD:275368	6/19 (32%)
		zf-H2C2_2	513..537	CDD:290200	9/23 (39%)
		C2H2 Zn finger	529..549	CDD:275368	8/19 (42%)
		zf-H2C2_2	542..566	CDD:290200	8/23 (35%)
		C2H2 Zn finger	557..577	CDD:275368	7/19 (37%)
		zf-H2C2_2	570..594	CDD:290200	11/23 (48%)
		C2H2 Zn finger	585..605	CDD:275368	7/19 (37%)
		zf-H2C2_2	597..621	CDD:290200	12/23 (52%)
		C2H2 Zn finger	613..633	CDD:275368	5/17 (29%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	162/409 (40%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900