DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF85 and CG8944

DIOPT Version :9

Sequence 1:	XP_011526565.1	Gene:	ZNF85 / 7639	HGNCID:	13160	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	652	Identity:	133/652 - (20%)
Similarity:	209/652 - (32%)	Gaps:	233/652 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   142 QKVTLKRYGKCRHENLPLRKGCESMDEC--------------KMHKGGCNGLNQCLTATQSKIFQ 192
            :|||.:|......|.|....|..|||:.              .|...|.:|:|.....|:|....
  Fly   166 KKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEYMDFAGFDGVNHSGFGTESDFLS 230

Human   193 CDKYVKVAHKFSNSNRHEIRHTK-------------KKPFKCTKCGKSFGMISCLTEHSRIHTRV 244
            .|:.|:  ......:|....|.|             :.||              |.:|.....|.
  Fly   231 YDEMVE--ESLLGRDREVTMHIKDRKMIQFLIHSYQRNPF--------------LWDHGNAQFRD 279

Human   245 NFYKCE-------ECGKAFN-----------WSSTLTKHKRIHTGEKPYKCEECGKAFNQSSNLI 291
            ...:..       |....||           |.:..|.:||           ||.:...:.:|:
  Fly   280 RVKRARFLDWIVLEFKSRFNISLAKDAITRKWDNLRTVYKR-----------ECNRMALEKTNI- 332

Human   292 KHKKIHTGEKPYKCEECGKTFNRFSTLTTHKIIHTGEKPYK---------CKECG--KAFNRSST 345
                                    |||...|.:|...:.|.         .||..  :.|:....
  Fly   333 ------------------------STLWYFKELHFLNEVYSYNDKMSDAVVKETSYRRRFSAIWN 373

Human   346 LTTHRKIHTGEKPYKCEECGKAFKQSSNLTTHKIIHTGEKPYKCK-KCGKAFNQSA-------HL 402
            .|:..|:.:..|.|:|                 ..:..:..|:.| :.|:..:|.|       .:
  Fly   374 DTSTAKLLSMVKRYQC-----------------FYNRFDPDYRSKERRGEGLHQMAIELQQLIDV 421

Human   403 TTHEVI---------HTGEKPYK--CEKCGKAF--NHFSHLTTHKIIHTGEKPYKCKECGKAFKH 454
            ||.::.         ::.:|..:  .|:.||.|  |:..:...| .:.....|:||..|.:..:.
  Fly   422 TTIQISKRISQLRFDYSKQKMERLNSERLGKKFIANYLYYDQMH-FMDDDIPPFKCAHCPEIVQT 485

Human   455 SSTLTKHKIIHTGEKP-----YKCKECEKAFNQSSKLTEHKKIHTG---EKPYECEKCGKAFNQS 511
            ...|..|.:.|   :|     |.|..|...|:.:.:...||::|.|   |..:.||.|..:|.:.
  Fly   486 LRELDLHMLTH---QPSLGGGYYCNICSIQFHNAQEFDNHKQLHLGGVTEIKFNCELCTASFREK 547

Human   512 SNLTRHKKSHTEE---------------------------------------------------- 524
            :|...|.:.|.||
  Fly   548 ANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEESRGSGSRRKRRHAAKATDDMVDDD 612

Human   525 -------------------KPYKCEECGKGFKWPSTLTIHKIIHTGEKP--YKCE--ECGKAFNQ 566
                               |||.|:.|.:.|..|..|..|:|:|..|:.  |||:  :|.|:|..
  Fly   613 DRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAHRIVHQDERERCYKCDYPQCNKSFVA 677

Human   567 SSKLTKHKKIHTGEKPYTCEECGKAFNQSSNLTKHKRIHTGEKPYKCEECDKAFKWSSVLTKHKI 631
            .:.|.:|.|.|...:.:.|:.|||.|..:.||..||:||...|.|.|:.|..||..::.|..||.
  Fly   678 RNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLHKR 742

Human   632 IH 633
            .|
  Fly   743 RH 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF85	XP_011526565.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	189..603	CDD:227381	104/559 (19%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	7/37 (19%)
		zf-H2C2_2	262..286	CDD:290200	5/23 (22%)
		C2H2 Zn finger	277..297	CDD:275368	3/19 (16%)
		zf-H2C2_2	289..314	CDD:290200	1/24 (4%)
		C2H2 Zn finger	305..325	CDD:275368	4/19 (21%)
		zf-H2C2_2	318..342	CDD:290200	7/34 (21%)
		C2H2 Zn finger	333..353	CDD:275368	5/21 (24%)
		zf-H2C2_2	346..370	CDD:290200	5/23 (22%)
		C2H2 Zn finger	361..381	CDD:275368	1/19 (5%)
		zf-H2C2_2	373..398	CDD:290200	3/25 (12%)
		C2H2 Zn finger	389..409	CDD:275368	6/36 (17%)
		zf-H2C2_2	401..426	CDD:290200	7/37 (19%)
		C2H2 Zn finger	417..437	CDD:275368	6/21 (29%)
		zf-H2C2_2	429..454	CDD:290200	5/24 (21%)
		C2H2 Zn finger	445..465	CDD:275368	4/19 (21%)
		zf-H2C2_2	458..482	CDD:290200	8/28 (29%)
		C2H2 Zn finger	473..493	CDD:275368	5/19 (26%)
		zf-H2C2_2	486..510	CDD:290200	9/26 (35%)
		C2H2 Zn finger	501..521	CDD:275368	6/19 (32%)
		zf-H2C2_2	513..537	CDD:290200	10/94 (11%)
		C2H2 Zn finger	529..549	CDD:275368	7/19 (37%)
		zf-H2C2_2	542..566	CDD:290200	11/27 (41%)
		C2H2 Zn finger	557..577	CDD:275368	7/21 (33%)
		zf-H2C2_2	570..594	CDD:290200	9/23 (39%)
		C2H2 Zn finger	585..605	CDD:275368	9/19 (47%)
		zf-H2C2_2	597..621	CDD:290200	11/23 (48%)
		C2H2 Zn finger	613..633	CDD:275368	7/19 (37%)
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	20/134 (15%)
		MADF	379..472	CDD:214738	18/110 (16%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		zf-C2H2_8	639..712	CDD:292531	25/72 (35%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	9/21 (43%)
		C2H2 Zn finger	696..716	CDD:275368	9/19 (47%)
		zf-H2C2_2	708..733	CDD:290200	12/24 (50%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000