DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF84 and Pitslre

DIOPT Version :9

Sequence 1:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens
Sequence 2:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	202	Identity:	43/202 - (21%)
Similarity:	65/202 - (32%)	Gaps:	59/202 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   134 GLILKHHLDL--LIPKGDYGKAESDDFNVFDNFFLHSKPEDTDTWLKYYDCDKYKESYKKSQIII 196
            |.|....|.:  |.|    ||:|.|:.|   ..|......:...|..|.:....|.       ::
  Fly   748 GCIFAEFLQMLPLFP----GKSEIDELN---RIFKELGTPNEKIWPGYTELPAVKN-------ML 798

Human   197 YHRNRLGEKLYECSECRKRFSKKPS---------LIKH--QSRHIRDIAFGCG-----------N 239
            ...::..|  |..|:.||.|.:|.|         |:.:  :.|...|.|...|           :
  Fly   799 SQNSQFTE--YPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPIDPS 861

Human   240 CGKTFPQKSQFITHHRTHTGEKPYNCSQCGKAFSQKSQLTSHQRTHTGEKPYECGECGKAFS--- 301
            ...|:|.||:........:..||   ...|..|.|..:          ::|...|...|..|
  Fly   862 MFPTWPAKSELGARKAQASSPKP---PSGGSQFKQLGR----------DEPIIVGPGNKLSSGII 913

Human   302 ---RKSH 305
               :|||
  Fly   914 TGNKKSH 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368	7/30 (23%)
		C2H2 Zn finger	237..257	CDD:275368	5/30 (17%)
		C2H2 Zn finger	265..285	CDD:275368	3/19 (16%)
		zf-H2C2_2	278..302	CDD:316026	4/29 (14%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		COG5048	317..724	CDD:227381
		C2H2 Zn finger	321..341	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..453	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..537	CDD:275368
		C2H2 Zn finger	545..565	CDD:275368
		C2H2 Zn finger	573..593	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	27/118 (23%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	27/121 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000