Protein Alignment CA5A and CAH2

DIOPT Version :10

• Sequence 1: NP_001730.1
• Gene: CA5A / 763
• HGNCID: 1377
• Length: 305
• Species: Homo sapiens
• Sequence 2: NP_648555.1
• Gene: CAH2 / 39390
• FlyBaseID: FBgn0027843
• Length: 335
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 82/262 - (31%)
• Similarity: 132/262 - (50%)
• Gaps: 31/262 - (11%)

Human    52 WTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSY----EAASCLYIWNTGYLFQVEFD-DATE 111
            |:...:...|..||||||   |.|...:.|..::.:    .....|.:.|.|:...|:.. :..|
  Fly    39 WSEDYARCSGKHQSPINI---DQVSAVEKKFPKLEFFNFKVVPDNLQMTNNGHTVLVKMSYNEDE 100

Human   112 ASGISGGPLENH----YRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVV 172
            ...:.||||...    |:.:|||||||..:..|||..::..|||||||:|..| ::|.::..|:.
  Fly   101 IPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVVLRN-LEYPDFASALD 164

Human   173 GENGLAVIGVFLKLGAHHQ-TLQRLVDILPEIKHKDARAAMRPFDPSTLLP-------TCWDYWT 229
            .::|:||:..|.::|.... ..:...::|.:|..|.....|     :..||       :...|::
  Fly   165 KDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNM-----TNPLPLGEYISKSVESYFS 224

Human   230 YAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWA 294
            |.|||||||.:|.||||....|:::...||:|||.|.     ..:..:.||:||:|||.:|.::.
  Fly   225 YTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLT-----ANDDHLKNNFRPIQPLNDRTLYK 284

Human   295 SF 296
            ::
  Fly   285 NY 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CA5A	NP_001730.1	alpha_CA_V	61..296	CDD:239392	81/251 (32%)
CAH2	NP_648555.1	Carb_anhydrase	34..286	CDD:459707	82/260 (32%)