DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ZNF76 and CG10348

DIOPT Version :9

Sequence 1:XP_011513148.1 Gene:ZNF76 / 7629 HGNCID:13149 Length:591 Species:Homo sapiens
Sequence 2:NP_001286059.1 Gene:CG10348 / 35132 FlyBaseID:FBgn0032707 Length:540 Species:Drosophila melanogaster


Alignment Length:359 Identity:88/359 - (24%)
Similarity:133/359 - (37%) Gaps:103/359 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   150 PARLFPQVLHDSQIPRNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSC 214
            |....|| |.|.|..|..|                .|...|..:...:......|| |.|.|  |
  Fly   272 PVLPHPQ-LQDYQTRRKNK----------------ARTAATGGNATPNLPQRNKDR-YTCKF--C 316

Human   215 GKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRT-HTGERPFQCPFEGCGRSF 278
            ||.|.....|..|:||||||:||||  :.|.::|..|.:||:|||. |..||||:|..       
  Fly   317 GKVFPRSANLTRHLRTHTGEQPYKC--KYCERSFSISSNLQRHVRNIHNKERPFKCEI------- 372

Human   279 TTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSS 343
                                     |.|.|...||...|::.|..:...:..:.|..:|.     
  Fly   373 -------------------------CERCFGQQTNLDRHLKKHESDAVSLSALSGVSERM----- 407

Human   344 LYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGEL--EATEESEQALYEQQQLE---AAS 403
                |.:...|:..|    .::|.:      ..||..|::  :..::.:|..::|||.:   .|:
  Fly   408 ----HCIRRFCENPT----EESYFE------EIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTAT 458

Human   404 AAEESPPPKR--PRIAYLSEVKEERDDIPAQVAMVTEEDGAPQVALITQDGAQQVSLSPEDLQAL 466
            :|..|....|  |..::     ||.|..|   |..|.:..||..:...::         ||.|.:
  Fly   459 SASSSCSSSRDTPTSSH-----EEADHAP---ATSTADTAAPSSSRDQEE---------EDSQPI 506

Human   467 GSAISMVTQHGSTTLTIPSPDADLATSGTHTVTM 500
                 |..:...|:...|:..||.|.:...|.::
  Fly   507 -----MELKRTLTSKLFPTTTADSAMTTPQTTSI 535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF76XP_011513148.1 C2H2 Zn finger 179..201 CDD:275368 2/21 (10%)
zf-H2C2_2 193..220 CDD:290200 9/26 (35%)
COG5048 204..>262 CDD:227381 29/58 (50%)
C2H2 Zn finger 209..231 CDD:275368 9/21 (43%)
zf-H2C2_2 224..250 CDD:290200 14/25 (56%)
zf-C2H2_aberr 237..358 CDD:293622 28/121 (23%)
C2H2 Zn finger 239..261 CDD:275368 9/22 (41%)
zf-H2C2_2 253..280 CDD:290200 11/27 (41%)
C2H2 Zn finger 269..291 CDD:275368 1/21 (5%)
zf-H2C2_2 285..310 CDD:290200 3/24 (13%)
C2H2 Zn finger 299..321 CDD:275368 6/21 (29%)
zf-H2C2_2 313..339 CDD:290200 5/25 (20%)
C2H2 Zn finger 329..351 CDD:275368 3/21 (14%)
C2H2 Zn finger 359..377 CDD:275368 1/17 (6%)
CG10348NP_001286059.1 COG5048 300..>363 CDD:227381 29/67 (43%)
zf-C2H2 311..333 CDD:278523 10/23 (43%)
C2H2 Zn finger 313..333 CDD:275368 9/21 (43%)
zf-H2C2_2 325..349 CDD:290200 13/25 (52%)
C2H2 Zn finger 341..362 CDD:275368 9/22 (41%)
zf-H2C2_2 353..377 CDD:290200 13/55 (24%)
zf-C2H2 368..390 CDD:278523 8/53 (15%)
C2H2 Zn finger 370..390 CDD:275368 7/51 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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