DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF74 and CG5245

DIOPT Version :9

Sequence 1:	NP_001243453.1	Gene:	ZNF74 / 7625	HGNCID:	13144	Length:	644	Species:	Homo sapiens
Sequence 2:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	156/460 - (33%)
Similarity:	230/460 - (50%)	Gaps:	78/460 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   202 KNVQATEGRTKAPARL--CAGENASTPSEPEKFPQVRRQRGAGAGEGEFVCGECGKAFRQSSSLT 264
            |:::..:|   .|::|  |..:.|      :|.| :|:|...      |.|.:|.|.|.:..:|.
  Fly    50 KDLEPVKG---VPSKLKTCKSKIA------KKRP-LRKQTDT------FKCTQCQKTFTRKENLE 98

Human   265 LHRRWHSREKAY---------------------------KCDECGKAFTWSTNLLEHRRIHTGEK 302
            .|.|.|:.|:.:                           ||..|.|.||.:::|.:|...||||:
  Fly    99 SHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGER 163

Human   303 PFFCGECGKAFSCHSSLNVHQRIHTGERPYKCSACEKAFSCSSLLSMHLRVHTGEKPYRCGECGK 367
            ||.|.:|..:|:..|.|.||.|.|:.|||::|:.|||||..:|.|..|||.|...:|::|..|.|
  Fly   164 PFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSK 228

Human   368 AFNQRTHLTRHHRIHTGEKPYQCGSCGKAFTCHSSLTVHEKIHSGDKPFKCSDCEKAFNSRSRLT 432
            :|..|:.|.:|...| .|:.::|..|.|.|..:.||.:|.::|:|:.||||..|.:.|...|||.
  Fly   229 SFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQ 292

Human   433 LHQRTHTGEKPFKCADCGKGFSCHAYLLVHRRIHSGEKPFKCNECGKAFSSHAYLIVHRRIHTGE 497
            ||...|.|::|.||:.|...|:..:...||.|:|:.|:.:||.||.|:|...::|:.|:::||||
  Fly   293 LHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGE 357

Human   498 KPFDCSQCWKAFSCHSSLIVHQRIHTGEKPYKCSECGRAFSQN-------------------HC- 542
            :||.|:.|:|.|.|.:.|.||...|.|||..|||.|.:.|..:                   ||
  Fly   358 RPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCS 422

Human   543 --------LIKHQKIHSGEKSFKCEKCGEMFNWSSHLTEHQRLHSEGKPLAIQFNKHLLSTYYVP 599
                    |..|.:.|:||..|||..|.::|..|:...||.|.|:..||    :.....||.|..
  Fly   423 KSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKP----YKCSHCSTRYTQ 483

Human   600 GSLLG 604
            .|.||
  Fly   484 KSSLG 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF74	NP_001243453.1	KRAB	43..103	CDD:214630
		COG5048	<248..395	CDD:227381	60/173 (35%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		COG5048	<331..511	CDD:227381	73/179 (41%)
		C2H2 Zn finger	334..354	CDD:275368	11/19 (58%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		C2H2 Zn finger	502..522	CDD:275368	8/19 (42%)
		zf-H2C2_2	514..539	CDD:372612	12/24 (50%)
		C2H2 Zn finger	530..550	CDD:275368	8/47 (17%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	143/415 (34%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	0/19 (0%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	14/24 (58%)
		C2H2 Zn finger	195..215	CDD:275368	11/19 (58%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	4/19 (21%)
		C2H2 Zn finger	418..438	CDD:275368	4/19 (21%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000