Protein Alignment CA4 and CAH1

DIOPT Version :10

• Sequence 1: XP_005257696.1
• Gene: CA4 / 762
• HGNCID: 1375
• Length: 336
• Species: Homo sapiens
• Sequence 2: NP_523561.1
• Gene: CAH1 / 34786
• FlyBaseID: FBgn0027844
• Length: 270
• Species: Drosophila melanogaster
• Alignment Length: 321
• Identity: 84/321 - (26%)
• Similarity: 123/321 - (38%)
• Gaps: 89/321 - (27%)

Human    22 HWCYEVQAESSNYPCLVPVKWG---GNCQKDRQSPINIVTTKAKVDKKLG--------------R 69
            ||.|   .|.:.     |..|.   ......||||::|..:.||...:|.              .
  Fly     4 HWGY---TEENG-----PAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKS 60

Human    70 FFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGL-PAPYQAKQLHLHWSDLPYKGSEHSLDGE 133
            ....||    .|.|..||..        :.::||.| ...::.:|.|.||.....|||||::||.
  Fly    61 LVNPGY----CWRVDVNGAD--------SELTGGPLGDQIFKLEQFHCHWGCTDSKGSEHTVDGV 113

Human   134 HFAMEMHIVH---EKEKGTSRNVKEAQDPEDEIAVLAFLVEIGRMNWPPPLAPCRLSQDPSL--- 192
            .::.|:|:||   .|.|    :..||....|.:|||...::.|..:       ..|.:..||
  Fly   114 SYSGELHLVHWNTTKYK----SFGEAAAAPDGLAVLGVFLKAGNHH-------AELDKVTSLLQF 167

Human   193 PFQAGTQVN--EGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDE 255
            ....|.:|.  :|..|                      ..|||   .:..|:.|.||||||.|.|
  Fly   168 VLHKGDRVTLPQGCDP----------------------GQLLP---DVHTYWTYEGSLTTPPCSE 207

Human   256 KVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKD-------NVRPLQQLGQRTVIKSG 309
            .|:|.||:.||::..:|:.|......||.::.....:       |.||...||:|.:.:.|
  Fly   208 SVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGKVINNFRPPLPLGKRELREIG 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CA4	XP_005257696.1	alpha_CA_IV_XV_like	48..307	CDD:239391	77/288 (27%)
CAH1	NP_523561.1	Carb_anhydrase	11..265	CDD:459707	79/306 (26%)