Protein Alignment CA3 and CAH16

DIOPT Version :10

• Sequence 1: NP_005172.1
• Gene: CA3 / 761
• HGNCID: 1374
• Length: 260
• Species: Homo sapiens
• Sequence 2: NP_001287620.1
• Gene: CAH16 / 50101
• FlyBaseID: FBgn0040628
• Length: 286
• Species: Drosophila melanogaster
• Alignment Length: 276
• Identity: 82/276 - (29%)
• Similarity: 135/276 - (48%)
• Gaps: 45/276 - (16%)

Human     4 EWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIR----------HDPSL--QPWSVSYDGGSA 56
            ||.|.. ||.| |.:|.  :.|::|||:.|.::..|          |...|  :|:.:..:|.|.
  Fly    25 EWNYLK-NGKD-WEDLC--SSGKHQSPILLDSRTARKWVLPGITFWHYYRLLKRPFYIRNNGHSI 85

Human    57 K---TILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAEL 118
            .   .:.:||:           :..:.||.|.|.|.....|.||||....||||.::..::.||:
  Fly    86 SLDIPVTSNGR-----------KPFITGGRLKGRYYADGLHFHWGSYKSRGSEHLINKRRFDAEI 139

Human   119 HLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENG----EFQIFLDALDKIKTKGKEAPFTKFD 179
            |:||.|.||....:|::|:||:||:.|.:.|..::.    .....::|:.::..:...|  |.|.
  Fly   140 HIVHRNEKYRNIAQAVRQKDGLAVVAIMVAIVRKDNAKSTPLSRLMEAVVRVPIEDSNA--TVFG 202

Human   180 PSCLFP-----ACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVP 239
            .|.|..     :.||::||:||.|||.|:|.:.|::..|..||:...::|...|.....:.
  Fly   203 QSSLDQLIGGVSHRDFFTYEGSLTTPLCDETVTWIVFTETTTVTMSSVSKFWLLRDHWGHR---- 263

Human   240 LVSNWRPPQPINNRVV 255
            |::|:|..|.:|||.|
  Fly   264 LINNYRIVQDLNNRTV 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CA3	NP_005172.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	82/276 (30%)
		Involved in proton transfer. /evidence=ECO:0000269|PubMed:17427958	64..67		0/2 (0%)
CAH16	NP_001287620.1	Carb_anhydrase	33..281	CDD:459707	77/267 (29%)