Protein Alignment CA3 and CAH9

DIOPT Version :10

• Sequence 1: NP_005172.1
• Gene: CA3 / 761
• HGNCID: 1374
• Length: 260
• Species: Homo sapiens
• Sequence 2: NP_651535.1
• Gene: CAH9 / 43264
• FlyBaseID: FBgn0039486
• Length: 311
• Species: Drosophila melanogaster
• Alignment Length: 274
• Identity: 82/274 - (29%)
• Similarity: 129/274 - (47%)
• Gaps: 34/274 - (12%)

Human     5 WGYASHNGPDHWHELFPNAKGENQSPVELHTKDIR--HDP--------SLQPWSVSYDGGSAKTI 59
            :||:..| ...|.....:..|:.|||:.:.|....  |.|        :|.|:.:.        :
  Fly    25 FGYSEPN-QRRWARHHGHCAGKTQSPIAITTSRTTAIHMPAVDMIGYHNLLPYPLK--------M 80

Human    60 LNNGKTCRVVFDDTYDRSM-------LRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAE 117
            :|||.|..:.........:       :||..|||.:.:...|.|||..::.||||.::.::|..|
  Fly    81 INNGHTVSITIPKVNVTEVGEDFLPYIRGAKLPGEFEVEGLHFHWGDKNNRGSEHVINDIRYTME 145

Human   118 LHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDA-LDKIKTKGKEAPF-TKFDP 180
            :|:||.|.||.|..|||...||.||:|.|..:..:.|...:.::. |..|....:||.. ..|..
  Fly   146 MHIVHRNKKYATIGEALNHPDGAAVLGFFFNLDEDEGAGLVTINRHLHLIADANQEATLNVTFSL 210

Human   181 SCLFPA--CRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSN 243
            |.|...  ...::||:||.|||||.|.:.|:|..:|:.:|..|:::.|.|..:.:.    .||.|
  Fly   211 SSLIAGVDVDKFYTYKGSLTTPPCSEAVTWILFPDPIPISPKQISRFRQLSDTQDG----ALVDN 271

Human   244 WRPPQPINNRVVRA 257
            :|..||:.||.:.|
  Fly   272 FRTLQPVGNRRIFA 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CA3	NP_005172.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	82/274 (30%)
		Involved in proton transfer. /evidence=ECO:0000269|PubMed:17427958	64..67		1/2 (50%)
CAH9	NP_651535.1	Carb_anhydrase	31..286	CDD:459707	80/268 (30%)