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Protein Alignment CA2 and CAH1

DIOPT Version :9

Sequence 1:	NP_000058.1	Gene:	CA2 / 760	HGNCID:	1373	Length:	260	Species:	Homo sapiens
Sequence 2:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster

Alignment Length:	273	Identity:	125/273 - (45%)
Similarity:	158/273 - (57%)	Gaps:	25/273 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLK--PLSVSYDQATSLRILNNG 63
            |||||||.:.|||.||.|::|.|.|.|||||||...:||....|.  ||...|....:..::|.|
  Fly     1 MSHHWGYTEENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSLVNPG 65

Human    64 HAFNVEFDDSQDKAVLKGGPL-DGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWN-TK 126
            :.:.|:.:.:..:  |.|||| |..::|.|||.|||..|.:|||||||...|:.|||||||| ||
  Fly    66 YCWRVDVNGADSE--LTGGPLGDQIFKLEQFHCHWGCTDSKGSEHTVDGVSYSGELHLVHWNTTK 128

Human   127 YGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADF-TNFDPRGLLPESLDY 190
            |..||:|...||||||||:|||.|:....|.||..:|..:..||..... ...||..|||:...|
  Fly   129 YKSFGEAAAAPDGLAVLGVFLKAGNHHAELDKVTSLLQFVLHKGDRVTLPQGCDPGQLLPDVHTY 193

Human   191 WTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLN------------FNGEGEPEELMVDN 243
            |||.|||||||..|.|.|||.|.||.||.:|:...|.||            |||:      :::|
  Fly   194 WTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGK------VINN 252

Human   244 WRPAQPLKNRQIK 256
            :||..||..|:::
  Fly   253 FRPPLPLGKRELR 265

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.