DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF45 and CG11247

DIOPT Version :9

Sequence 1:	NP_003416.1	Gene:	ZNF45 / 7596	HGNCID:	13111	Length:	682	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	129/456 - (28%)
Similarity:	195/456 - (42%)	Gaps:	100/456 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   116 IKYQDSVVNIQRTGCQLEKRDDLHYKDEGFSNQSSHLQVHRVHTGEKPYKGEHCVKSFSWSSHLQ 180
            ||.:.|.:...|..|..|:.||                     .||:..|.:..|:.       |
  Fly    41 IKRRKSSLASLRDACVDEEEDD---------------------GGEQDSKDDDYVQP-------Q 77

Human   181 INQRAHAGE----KPYKCEKCDNAFRRFSSLQAHQRVHSRAKSYTNDASYRSFSQRSHLPHHQRV 241
            :.:.|..||    |.:.|.:|...|...:.||.|
  Fly    78 LKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRH------------------------------- 111

Human   242 PTGENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHL-KVHTGKKPYK 305
                                     :::|:.|:|:||::||..:.|...|:.|: ..|..:|.:.
  Fly   112 -------------------------MLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFV 151

Human   306 CEECGKSFSWRSRLQAHERIHTGEKPYKCNACGKSFSYSSHLNIHCRIH--TGEKPYKCEECGKG 368
            |.:|.|||:.:.||:.|.|:|:|||||.|:.|.|.|:....|..|...|  |..:.:.|.:|...
  Fly   152 CSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSAS 216

Human   369 FSVGSHLQAHQISHTGEKPYKCEECGKGFCRASNLLDH-QRGHTGEKPYQCDACGKGFSRSSDFN 432
            ||..::|:.|...|.....::|..|...|.....|..| .:.|.....::|:.|.|......|..
  Fly   217 FSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLA 281

Human   433 IHFRVHTGEKPYKCEECGKGFSQASNLLAHQRGHTGEKPYKCGTCGKGFSRSSDLNVHCRIHTGE 497
            .|.:.||..|.:.||.|...|:|.|....|.|.||||:||:|..|.:.|:.||.|.:|.|.||||
  Fly   282 THMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346

Human   498 KPYKCERCGK--AFSQFSSLQVH-QRVHTGEKPYQCAECGKGFSVGSQLQAH-QRCH----TGEK 554
            ||::|:.|..  ||||.:.|:.| :::|..:|||.|..|...|.:..:||:| :.|.    .|:|
  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVDGDK 411

Human   555 P 555
            |
  Fly   412 P 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF45	NP_003416.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	166..186	CDD:275368	2/19 (11%)
		COG5048	190..602	CDD:227381	113/378 (30%)
		C2H2 Zn finger	194..214	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..270	CDD:275368	0/18 (0%)
		C2H2 Zn finger	278..298	CDD:275368	6/20 (30%)
		zf-H2C2_2	290..314	CDD:290200	8/24 (33%)
		C2H2 Zn finger	306..326	CDD:275368	9/19 (47%)
		zf-H2C2_2	319..343	CDD:290200	13/23 (57%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		zf-H2C2_2	346..370	CDD:290200	6/25 (24%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	374..397	CDD:290200	5/22 (23%)
		C2H2 Zn finger	390..410	CDD:275368	5/20 (25%)
		zf-H2C2_2	402..427	CDD:290200	6/25 (24%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		zf-H2C2_2	430..455	CDD:290200	9/24 (38%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	458..483	CDD:290200	11/24 (46%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
		zf-H2C2_2	486..511	CDD:290200	13/26 (50%)
		C2H2 Zn finger	502..522	CDD:275368	8/22 (36%)
		zf-H2C2_2	514..538	CDD:290200	8/24 (33%)
		C2H2 Zn finger	530..550	CDD:275368	6/20 (30%)
		zf-H2C2_2	543..565	CDD:290200	7/18 (39%)
		C2H2 Zn finger	558..578	CDD:275368
		zf-H2C2_2	570..595	CDD:290200
		zf-C2H2	584..606	CDD:278523
		C2H2 Zn finger	586..606	CDD:275368
		zf-H2C2_2	598..622	CDD:290200
		C2H2 Zn finger	614..634	CDD:275368
		zf-H2C2_2	626..650	CDD:290200
		C2H2 Zn finger	642..662	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..682
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/214 (24%)
		C2H2 Zn finger	95..115	CDD:275368	6/75 (8%)
		zf-H2C2_2	107..132	CDD:290200	10/80 (13%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	60/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910