DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF43 and CG4936

DIOPT Version :9

Sequence 1:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens
Sequence 2:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	139/517 - (26%)
Similarity:	212/517 - (41%)	Gaps:	111/517 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   292 EKFYKCKEC--------AKAFNQSS--NLTEHKKIHPGEKPYK---------CEECGK----AFN 333
            :|:..|:.|        |..||..|  :|| |.....|..|.|         ||:|.|    ||.
  Fly    18 QKWIVCRVCLQQPKEPMASIFNDDSEKDLT-HMIRECGGVPIKQFDHYPDKICEKCFKVLKMAFK 81

Human   334 WPSTLTK---HKRIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLT 395
            :..|..:   |.|...|  |...|:         .....|...||.|.....:..||.....:..
  Fly    82 FRETCQRSYGHLRQFVG--PVEVEQ---------RPPEKKGSETATKLEPDVDPDEAEQEPEHDE 135

Human   396 KHKKIHTEKKPY-----KCEECGKAFKWS------SKLTEHKLTHTGEKPYKCEECG---KAFNW 446
            :.:.:..::..|     ..|..|..|...      .:|.:.::.|.  |..:.||.|   :.::.
  Fly   136 EDEDVDLDESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHV--KNEQVEEDGIIEEVYDV 198

Human   447 PSTLTKHNRIHTG----EKPYKCEVCGKAFNQFS------------NLT--THK-----RIHTAE 488
            ..|       :.|    ::.|..|:..:|.::.|            .||  .|:     .:::.|
  Fly   199 YET-------YEGDLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTE 256

Human   489 KPYKCEECGKAFSRSSNLTKHK-----------KIHIEKKPYKCEECG---KAFKWSSKLTEHKI 539
            :.:...:..:|...:.|.||.:           .:.:|....|..:.|   |..:.:|.....|:
  Fly   257 EEFVPSKSVRASIHARNATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKM 321

Human   540 THTGEKPYKCEECGKAFNHFSILTK--HKRIHTGEKPYK--CEECGKAFTQSSNLTTHKKIHTGE 600
            :...||.....|. .|..|..|.||  ||.:...:|.:|  |:.||..:...|.||.|.|:|:|.
  Fly   322 SIKSEKDISIGEV-LARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGV 385

Human   601 KFYKCEECGKAFTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECG 665
            |.::||.||..|.|:..|..|...|||.:||||..|..||...||..||..|||.|:||:|:.|.
  Fly   386 KPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCH 450

Human   666 KAFKWSSTLTKHKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRS 727
            |.|.:::||..||:|||||||:.|:.|||.|..:..|..|::||        |:.|::...|
  Fly   451 KTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH--------ERRGQSARES 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	138/514 (27%)
		C2H2 Zn finger	297..317	CDD:275368	9/29 (31%)
		zf-H2C2_2	309..333	CDD:290200	11/36 (31%)
		C2H2 Zn finger	325..345	CDD:275368	9/26 (35%)
		zf-H2C2_2	338..362	CDD:290200	5/26 (19%)
		C2H2 Zn finger	353..373	CDD:275368	2/19 (11%)
		C2H2 Zn finger	381..401	CDD:275368	2/19 (11%)
		zf-H2C2_2	393..417	CDD:290200	3/28 (11%)
		C2H2 Zn finger	409..429	CDD:275368	4/25 (16%)
		zf-H2C2_2	422..445	CDD:290200	6/25 (24%)
		C2H2 Zn finger	437..457	CDD:275368	4/22 (18%)
		zf-H2C2_2	450..474	CDD:290200	4/27 (15%)
		C2H2 Zn finger	465..485	CDD:275368	6/38 (16%)
		zf-H2C2_2	477..502	CDD:290200	5/31 (16%)
		C2H2 Zn finger	521..541	CDD:275368	4/22 (18%)
		zf-H2C2_2	534..558	CDD:290200	5/23 (22%)
		C2H2 Zn finger	549..569	CDD:275368	8/21 (38%)
		zf-H2C2_2	562..586	CDD:290200	9/27 (33%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		zf-H2C2_2	589..614	CDD:290200	12/24 (50%)
		C2H2 Zn finger	605..625	CDD:275368	8/19 (42%)
		zf-H2C2_2	617..642	CDD:290200	12/24 (50%)
		C2H2 Zn finger	633..653	CDD:275368	8/19 (42%)
		C2H2 Zn finger	661..681	CDD:275368	8/19 (42%)
		zf-H2C2_2	674..697	CDD:290200	14/22 (64%)
		C2H2 Zn finger	689..709	CDD:275368	7/19 (37%)
		zf-H2C2_2	702..726	CDD:290200	6/23 (26%)
		C2H2 Zn finger	717..737	CDD:275368	3/11 (27%)
		zf-H2C2_2	729..754	CDD:290200
		COG5048	742..>803	CDD:227381
		C2H2 Zn finger	745..765	CDD:275368
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	20/73 (27%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		zf-H2C2_2	375..399	CDD:290200	12/23 (52%)
		COG5048	386..>447	CDD:227381	29/60 (48%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	459..481	CDD:290200	14/21 (67%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910