DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF43 and CG4854

DIOPT Version :9

Sequence 1:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens
Sequence 2:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster

Alignment Length:	174	Identity:	67/174 - (38%)
Similarity:	93/174 - (53%)	Gaps:	19/174 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   349 KPYTC--EECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEE 411
            ||.|.  |:.|:|.:                 :.|..|...:|....||.|.|:|:.|||::||.
  Fly   163 KPVTFEDEDSGQAAS-----------------FTCNICNNVYSERVKLTNHMKVHSAKKPHECEI 210

Human   412 CGKAFKWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFS 476
            |.|.|:.:.:|..|..||||.:||||:.|...|..|||..||.||||.|:|||||.|.::|...:
  Fly   211 CHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIHTNERPYKCEFCSRSFGYSN 275

Human   477 NLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYK 520
            .|..|.:.||.|:|:.|:.|.|:||:..:...|:|.|...|..|
  Fly   276 VLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKRTKEVK 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	67/174 (39%)
		C2H2 Zn finger	297..317	CDD:275368
		zf-H2C2_2	309..333	CDD:290200
		C2H2 Zn finger	325..345	CDD:275368
		zf-H2C2_2	338..362	CDD:290200	6/14 (43%)
		C2H2 Zn finger	353..373	CDD:275368	3/21 (14%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	393..417	CDD:290200	12/23 (52%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		zf-H2C2_2	422..445	CDD:290200	11/22 (50%)
		C2H2 Zn finger	437..457	CDD:275368	9/19 (47%)
		zf-H2C2_2	450..474	CDD:290200	14/23 (61%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
		zf-H2C2_2	477..502	CDD:290200	10/24 (42%)
		C2H2 Zn finger	521..541	CDD:275368	67/174 (39%)
		zf-H2C2_2	534..558	CDD:290200
		C2H2 Zn finger	549..569	CDD:275368
		zf-H2C2_2	562..586	CDD:290200
		C2H2 Zn finger	577..597	CDD:275368
		zf-H2C2_2	589..614	CDD:290200
		C2H2 Zn finger	605..625	CDD:275368
		zf-H2C2_2	617..642	CDD:290200
		C2H2 Zn finger	633..653	CDD:275368
		C2H2 Zn finger	661..681	CDD:275368
		zf-H2C2_2	674..697	CDD:290200
		C2H2 Zn finger	689..709	CDD:275368
		zf-H2C2_2	702..726	CDD:290200
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..754	CDD:290200
		COG5048	742..>803	CDD:227381
		C2H2 Zn finger	745..765	CDD:275368
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		zf-H2C2_2	193..217	CDD:290200	13/23 (57%)
		COG5048	201..>258	CDD:227381	28/56 (50%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..244	CDD:290200	11/22 (50%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		zf-H2C2_2	251..273	CDD:290200	14/21 (67%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..301	CDD:290200	10/23 (43%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910