DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF43 and M1BP

DIOPT Version :9

Sequence 1:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	206	Identity:	69/206 - (33%)
Similarity:	98/206 - (47%)	Gaps:	28/206 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   556 FNHFSILTKH--------------KRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCE 606
            :.|.:|:.|.              :|..|| ..|.||:||...........|.:.|.|:|.:.||
  Fly   219 YEHENIVVKKCSLPPKPKVRSDDARRRGTG-GVYICEQCGNHIKGRMAFELHCRRHRGDKQFGCE 282

Human   607 ECGKAFTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWS 671
            .|...|..:|.|..|.:.|||.:|:.|:.||:.|..::|..||:..||.|:||.|..|||||...
  Fly   283 LCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTTRVKHERTHTNERPYVCGTCGKAFTTG 347

Human   672 STLTKHKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIEHKKI 736
            ..|..|.:||:||:.|:||.|.|:|.|.:.||||  ..:|......||.           |.|::
  Fly   348 YILKNHMLIHSGERAYRCELCDKSFMLPTHLSTH--FRSGVHKRHLEKA-----------EMKQV 399

Human   737 HTGEQPYKCEE 747
            ...||..:.:|
  Fly   400 LEQEQKRELKE 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	69/206 (33%)
		C2H2 Zn finger	297..317	CDD:275368
		zf-H2C2_2	309..333	CDD:290200
		C2H2 Zn finger	325..345	CDD:275368
		zf-H2C2_2	338..362	CDD:290200
		C2H2 Zn finger	353..373	CDD:275368
		C2H2 Zn finger	381..401	CDD:275368
		zf-H2C2_2	393..417	CDD:290200
		C2H2 Zn finger	409..429	CDD:275368
		zf-H2C2_2	422..445	CDD:290200
		C2H2 Zn finger	437..457	CDD:275368
		zf-H2C2_2	450..474	CDD:290200
		C2H2 Zn finger	465..485	CDD:275368
		zf-H2C2_2	477..502	CDD:290200
		C2H2 Zn finger	521..541	CDD:275368
		zf-H2C2_2	534..558	CDD:290200	0/1 (0%)
		C2H2 Zn finger	549..569	CDD:275368	4/26 (15%)
		zf-H2C2_2	562..586	CDD:290200	9/37 (24%)
		C2H2 Zn finger	577..597	CDD:275368	5/19 (26%)
		zf-H2C2_2	589..614	CDD:290200	8/24 (33%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		zf-H2C2_2	617..642	CDD:290200	10/24 (42%)
		C2H2 Zn finger	633..653	CDD:275368	7/19 (37%)
		C2H2 Zn finger	661..681	CDD:275368	8/19 (42%)
		zf-H2C2_2	674..697	CDD:290200	11/22 (50%)
		C2H2 Zn finger	689..709	CDD:275368	10/19 (53%)
		zf-H2C2_2	702..726	CDD:290200	7/23 (30%)
		C2H2 Zn finger	717..737	CDD:275368	4/19 (21%)
		zf-H2C2_2	729..754	CDD:290200	5/19 (26%)
		COG5048	742..>803	CDD:227381	1/6 (17%)
		C2H2 Zn finger	745..765	CDD:275368	1/3 (33%)
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		COG5048	276..>331	CDD:227381	20/54 (37%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:290200	9/23 (39%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		zf-H2C2_2	324..346	CDD:290200	13/21 (62%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..372	CDD:290200	11/21 (52%)
		C2H2 Zn finger	365..383	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910