DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF43 and ranshi

DIOPT Version :9

Sequence 1:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens
Sequence 2:	NP_649824.1	Gene:	ranshi / 41041	FlyBaseID:	FBgn0037620	Length:	346	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	89/356 - (25%)
Similarity:	139/356 - (39%)	Gaps:	66/356 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   297 CKECAKAFNQSSNLT----------EHKKIHPGEKPYKCEECGKAFNWPSTLTKHKRIHTGEKPY 351
            |:.|.|..|...:|.          ||.|:..|.....|          |||...
  Fly     6 CRTCGKRTNAERSLNIFEKRNQTTLEHIKLLTGAVLKNC----------STLPNR---------- 50

Human   352 TCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAF 416
            .|..|.....|  .::..:|....::....::..|.|.|....:....:..|:......|.....
  Fly    51 LCASCQTCLQQ--AISFRERCLEVQRELLHSQDDEDFLRICQESPKSVLEQEELELDLAEISIEV 113

Human   417 KWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYK----------------C 465
            :....|.|..:..:|   :|.|:          :...::|:..|...:                .
  Fly   114 ERLDDLNEGPIQSSG---FKVED----------ILNESKINEDEPNNEDDIDYSEMDYLIYESDT 165

Human   466 EVCGKAFNQFSNLTTHKRIH-----TAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECG 525
            ||..|...:..:....||.:     .:.:.:.|||||.......:...|.|.|...|.:.||.|.
  Fly   166 EVDAKQELKSDSENPKKRRNRRNPRDSNRTFFCEECGNHIKDRISFILHCKRHRGVKEFGCEFCE 230

Human   526 KAFKWSSKLTEHKITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNL 590
            ..|...::|..|...||||||:||..|.::|:.:|...||:|.||.|:|:.|:||..|||.|..|
  Fly   231 DRFCTPAELKRHIRKHTGEKPFKCRHCSRSFSDYSTRLKHERTHTNERPFVCKECNNAFTTSYIL 295

Human   591 TTHKKIHTGEKFYKCEECGKAFTQSSNLTTH 621
            ..|..:|||||.::|:.|.|.|::.::||||
  Fly   296 KNHMLVHTGEKAFRCDLCDKLFSRYTHLTTH 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	89/356 (25%)
		C2H2 Zn finger	297..317	CDD:275368	8/29 (28%)
		zf-H2C2_2	309..333	CDD:290200	6/33 (18%)
		C2H2 Zn finger	325..345	CDD:275368	4/19 (21%)
		zf-H2C2_2	338..362	CDD:290200	3/23 (13%)
		C2H2 Zn finger	353..373	CDD:275368	4/19 (21%)
		C2H2 Zn finger	381..401	CDD:275368	3/19 (16%)
		zf-H2C2_2	393..417	CDD:290200	2/23 (9%)
		C2H2 Zn finger	409..429	CDD:275368	3/19 (16%)
		zf-H2C2_2	422..445	CDD:290200	5/22 (23%)
		C2H2 Zn finger	437..457	CDD:275368	1/19 (5%)
		zf-H2C2_2	450..474	CDD:290200	5/39 (13%)
		C2H2 Zn finger	465..485	CDD:275368	5/19 (26%)
		zf-H2C2_2	477..502	CDD:290200	7/29 (24%)
		C2H2 Zn finger	521..541	CDD:275368	6/19 (32%)
		zf-H2C2_2	534..558	CDD:290200	12/23 (52%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		zf-H2C2_2	562..586	CDD:290200	12/23 (52%)
		C2H2 Zn finger	577..597	CDD:275368	9/19 (47%)
		zf-H2C2_2	589..614	CDD:290200	11/24 (46%)
		C2H2 Zn finger	605..625	CDD:275368	8/17 (47%)
		zf-H2C2_2	617..642	CDD:290200	4/5 (80%)
		C2H2 Zn finger	633..653	CDD:275368
		C2H2 Zn finger	661..681	CDD:275368
		zf-H2C2_2	674..697	CDD:290200
		C2H2 Zn finger	689..709	CDD:275368
		zf-H2C2_2	702..726	CDD:290200
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..754	CDD:290200
		COG5048	742..>803	CDD:227381
		C2H2 Zn finger	745..765	CDD:275368
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
ranshi	NP_649824.1	zf-AD	5..77	CDD:214871	17/92 (18%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		COG5048	222..>276	CDD:227381	22/53 (42%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	11/23 (48%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	269..291	CDD:290200	12/21 (57%)
		C2H2 Zn finger	282..302	CDD:275368	9/19 (47%)
		zf-H2C2_2	295..319	CDD:290200	11/23 (48%)
		C2H2 Zn finger	310..328	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000