DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF41 and Zfp74

DIOPT Version :9

Sequence 1:	NP_001311084.1	Gene:	ZNF41 / 7592	HGNCID:	13107	Length:	821	Species:	Homo sapiens
Sequence 2:	NP_001258268.1	Gene:	Zfp74 / 365224	RGDID:	1563223	Length:	683	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	350/765 - (45%)
Similarity:	447/765 - (58%)	Gaps:	111/765 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    69 VSFEDVTVDFSKEEWQHLDPAQRRLYWDVTLENYSHLLSVGYQIPKSEAAFKLEQGEGPWMLEGE 133
            |:|:||.:||:.|||:.|||.||.||.:|.||||::|::||..:.|.:..|||||.|.|.::|.|
  Rat     8 VTFKDVAIDFTPEEWKQLDPTQRNLYRNVMLENYNNLITVGPPLSKPDVIFKLEQEEEPCVVEKE 72

Human   134 APHQSCSGEAIGKMQQQGIPGGIFFHCERFDQPIGEDSLCSILEELWQDNDQLEQRQENQNNLLS 198
            ...:...||.:|                                        :::.|:|||.||.
  Rat    73 VLRRRRPGEILG----------------------------------------IDEHQKNQNRLLR 97

Human   199 HVKVLIKERGYEHKNIEKIIHVTTKLVPSIKRLHNCDTILKHTLNSHNHNRNSATKNLGKIFGNG 263
            .|                                     ||.|:.:|..:...      |.|.|
  Rat    98 QV-------------------------------------LKGTVVTHEADERP------KKFAN- 118

Human   264 NNFPHSPSSTKNENAKTGANSCEHDHYEKHLSHKQA-PTHHQKIHPEEKL--------------- 312
               ..||:|   ::..:|.|.|:.|...|....... |.:.::..|||:.
  Rat   119 ---TFSPNS---DSVPSGHNLCDPDSVGKRAEPDSGDPGNAKQPSPEERFQEDDAEQPFHNSSPH 177

Human   313 -----YVCTECVMGFTQKSHLFEHQRIHAGEKSRECDKSNKVFPQKPQVDVHPSVYTGEKPYLCT 372
                 :.|..|..||:|...|..|.|:|.|.|..||.:..|.|..|.::..|..:::.::.|.|.
  Rat   178 FVLTPFKCNHCGKGFSQTLDLIRHLRVHTGGKLYECHQCGKGFSHKEKLINHHKLHSRDQCYECN 242

Human   373 QCGKVFTLKSNLITHQKIHTGQKPYKCSECGKAFFQRSDLFRHLRIHTGEKPYECSECGKGFSQN 437
            :|||.|...|||:.||:||||:|||.|.||||:|.|:|:|..|.:||||||||||.||||.|||.
  Rat   243 ECGKTFIKMSNLMRHQRIHTGEKPYVCQECGKSFSQKSNLIDHEKIHTGEKPYECRECGKSFSQK 307

Human   438 SDLSIHQKTHTGEKHYECNECGKAFTRKSALRMHQRIHTGEKPYVCADCGKAFIQKSHFNTHQRI 502
            ..|..|||.|||||.|.||||||||.|.::|.:|.|.|||||||.|..|||||.|.|....|.||
  Rat   308 QSLVAHQKVHTGEKPYACNECGKAFPRIASLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRI 372

Human   503 HTGEKPYECSDCGKSFTKKSQLHVHQRIHTGEKPYICTECGKVFTHRTNLTTHQKTHTGEKPYMC 567
            ||||||||||:|||:|::.|.|.||.|.|||||||.|.||.|.|:|:.|..||||.||.||||.|
  Rat   373 HTGEKPYECSECGKAFSQSSALTVHIRSHTGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGC 437

Human   568 AECGKAFTDQSNLIKHQKTHTGEKPYKCNGCGKAFIWKSRLKIHQKSHIGERHYECKDCGKAFIQ 632
            .||||||...|||::||:.|||||||.|..|||||..||.|..|:|.|.||:.|||.:|||||.|
  Rat   438 NECGKAFIQMSNLVRHQRIHTGEKPYLCKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQ 502

Human   633 KSTLSVHQRIHTGEKPYVCPECGKAFIQKSHFIAHHRIHTGEKPYECSDCGKCFTKKSQLRVHQK 697
            |.....||::|||||||.|.:|||||.|.:....|.|.||||:||||..|||.|::.|.|.:|.:
  Rat   503 KQNFITHQKVHTGEKPYDCNKCGKAFSQIASLTLHLRSHTGERPYECDKCGKAFSQCSLLNLHMR 567

Human   698 IHTGEKPNICAECGKAFTDRSNLITHQKIHTREKPYECGDCGKTFTWKSRLNIHQKSHTGERHYE 762
            .||||||.||.||||||:.|::||.|.:.||.||||||..|||.|:..|.|.||.:.||||:.::
  Rat   568 SHTGEKPYICNECGKAFSQRTSLIVHMRGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFD 632

Human   763 CSKCGKAFIQKATLSMHQIIHTGKKPYACTECQKAFTDRSNLIKHQKMHS 812
            ||||||||.|.::|::|...|||:|||.|.||.|||:.:|:|::||::|:
  Rat   633 CSKCGKAFSQISSLTLHMRKHTGEKPYNCIECGKAFSQKSHLVRHQRIHT 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF41	NP_001311084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		KRAB	69..129	CDD:214630	32/59 (54%)
		KRAB	69..108	CDD:279668	22/38 (58%)
		C2H2 Zn finger	315..335	CDD:275368	8/19 (42%)
		COG5048	346..768	CDD:227381	250/421 (59%)
		C2H2 Zn finger	371..391	CDD:275368	10/19 (53%)
		zf-H2C2_2	383..406	CDD:290200	16/22 (73%)
		C2H2 Zn finger	399..419	CDD:275368	10/19 (53%)
		zf-H2C2_2	411..436	CDD:290200	17/24 (71%)
		C2H2 Zn finger	427..447	CDD:275368	12/19 (63%)
		zf-H2C2_2	439..464	CDD:290200	18/24 (75%)
		C2H2 Zn finger	455..475	CDD:275368	12/19 (63%)
		zf-H2C2_2	467..492	CDD:290200	16/24 (67%)
		C2H2 Zn finger	483..503	CDD:275368	10/19 (53%)
		zf-H2C2_2	495..519	CDD:290200	16/23 (70%)
		C2H2 Zn finger	511..531	CDD:275368	11/19 (58%)
		zf-H2C2_2	526..548	CDD:290200	15/21 (71%)
		C2H2 Zn finger	539..559	CDD:275368	11/19 (58%)
		zf-H2C2_2	551..575	CDD:290200	17/23 (74%)
		C2H2 Zn finger	567..587	CDD:275368	12/19 (63%)
		zf-H2C2_2	579..602	CDD:290200	15/22 (68%)
		C2H2 Zn finger	595..615	CDD:275368	11/19 (58%)
		C2H2 Zn finger	623..643	CDD:275368	10/19 (53%)
		zf-H2C2_2	636..660	CDD:290200	15/23 (65%)
		C2H2 Zn finger	651..671	CDD:275368	9/19 (47%)
		zf-C2H2	677..699	CDD:278523	10/21 (48%)
		C2H2 Zn finger	679..699	CDD:275368	8/19 (42%)
		C2H2 Zn finger	707..727	CDD:275368	11/19 (58%)
		zf-H2C2_2	719..743	CDD:290200	14/23 (61%)
		C2H2 Zn finger	735..755	CDD:275368	9/19 (47%)
		C2H2 Zn finger	763..783	CDD:275368	11/19 (58%)
		C2H2 Zn finger	791..811	CDD:275368	10/19 (53%)
Zfp74	NP_001258268.1	KRAB	8..68	CDD:214630	32/59 (54%)
		KRAB	8..47	CDD:279668	22/38 (58%)
		C2H2 Zn finger	185..205	CDD:275368	8/19 (42%)
		COG5048	236..677	CDD:227381	267/440 (61%)
		C2H2 Zn finger	241..261	CDD:275368	10/19 (53%)
		zf-H2C2_2	253..278	CDD:290200	17/24 (71%)
		C2H2 Zn finger	269..289	CDD:275368	10/19 (53%)
		zf-H2C2_2	281..306	CDD:290200	17/24 (71%)
		C2H2 Zn finger	297..317	CDD:275368	12/19 (63%)
		zf-H2C2_2	309..332	CDD:290200	16/22 (73%)
		C2H2 Zn finger	325..345	CDD:275368	12/19 (63%)
		zf-H2C2_2	337..362	CDD:290200	16/24 (67%)
		C2H2 Zn finger	353..373	CDD:275368	10/19 (53%)
		zf-H2C2_2	365..390	CDD:290200	17/24 (71%)
		C2H2 Zn finger	381..401	CDD:275368	11/19 (58%)
		zf-H2C2_2	393..418	CDD:290200	16/24 (67%)
		C2H2 Zn finger	409..429	CDD:275368	11/19 (58%)
		C2H2 Zn finger	437..457	CDD:275368	12/19 (63%)
		zf-H2C2_2	449..474	CDD:290200	17/24 (71%)
		C2H2 Zn finger	465..485	CDD:275368	11/19 (58%)
		zf-H2C2_2	477..502	CDD:290200	14/24 (58%)
		C2H2 Zn finger	493..513	CDD:275368	10/19 (53%)
		zf-H2C2_2	505..530	CDD:290200	15/24 (63%)
		C2H2 Zn finger	521..541	CDD:275368	9/19 (47%)
		zf-H2C2_2	533..558	CDD:290200	14/24 (58%)
		C2H2 Zn finger	549..569	CDD:275368	8/19 (42%)
		zf-H2C2_2	562..586	CDD:290200	16/23 (70%)
		C2H2 Zn finger	577..597	CDD:275368	11/19 (58%)
		zf-H2C2_2	589..614	CDD:290200	15/24 (63%)
		C2H2 Zn finger	605..625	CDD:275368	9/19 (47%)
		zf-H2C2_2	617..642	CDD:290200	15/24 (63%)
		C2H2 Zn finger	633..653	CDD:275368	11/19 (58%)
		zf-H2C2_2	645..670	CDD:290200	14/24 (58%)
		C2H2 Zn finger	661..681	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG35603
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820