DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ZNF37A and CG15436

DIOPT Version :9

Sequence 1:NP_001007095.1 Gene:ZNF37A / 7587 HGNCID:13102 Length:561 Species:Homo sapiens
Sequence 2:NP_608840.1 Gene:CG15436 / 33657 FlyBaseID:FBgn0031610 Length:346 Species:Drosophila melanogaster


Alignment Length:244 Identity:91/244 - (37%)
Similarity:131/244 - (53%) Gaps:29/244 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   271 YECHECGKTFTQKSAHTRHQRTHTGGKPYECHECGKTFYKNSDLIKHQRIHTGERPYGCHECGKS 335
            :||.||.|.:.:|....||.|||..|:.:.|                        ||    |.::
  Fly   126 FECRECHKKYQRKGTFLRHMRTHMDGQSFPC------------------------PY----CKRN 162

Human   336 FSEKSTLTQHQRTHTGEKPYECHECGKTFSFKSVLTVHQKTHTGEKPYECYACGKAFLRKSDLIK 400
            |..:.||..|.:||...|||||..|.|||:.:|.|..|::|||||:|::|..|.|.|::.|||.:
  Fly   163 FRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRR 227

Human   401 HQRIHTGEKPYECNECGKSFSEKSTLTKHLRTHTGEKPYECIQCGKFFCYYSGFTEHLRRHTGEK 465
            |.|.|..|:|::|::|.|:|:.|..|..|.|:||||:|::|..|.|.|.......:|.|.|..::
  Fly   228 HIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDR 292

Human   466 PFGCNECGKTFRQKSALIVHQRTHIRQKPYGCNQCGKSFCVKSKLIAHH 514
            ||.|:.|.||||..|.|..|:..|..::.:.|..|. ||..:.|.:|.|
  Fly   293 PFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCA-SFYKQRKTLARH 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF37ANP_001007095.1 KRAB 8..68 CDD:214630
C2H2 Zn finger 148..164 CDD:275368
C2H2 Zn finger 246..265 CDD:275368
COG5048 <269..421 CDD:227381 55/149 (37%)
C2H2 Zn finger 273..293 CDD:275368 8/19 (42%)
C2H2 Zn finger 301..321 CDD:275368 1/19 (5%)
C2H2 Zn finger 329..349 CDD:275368 5/19 (26%)
C2H2 Zn finger 357..377 CDD:275368 8/19 (42%)
C2H2 Zn finger 385..405 CDD:275368 9/19 (47%)
C2H2 Zn finger 413..433 CDD:275368 8/19 (42%)
zf-H2C2_2 426..448 CDD:316026 11/21 (52%)
C2H2 Zn finger 441..461 CDD:275368 6/19 (32%)
C2H2 Zn finger 469..489 CDD:275368 9/19 (47%)
COG5048 492..>552 CDD:227381 7/23 (30%)
C2H2 Zn finger 497..517 CDD:275368 7/18 (39%)
C2H2 Zn finger 525..545 CDD:275368
CG15436NP_608840.1 zf-AD 4..78 CDD:285071
C2H2 Zn finger 128..148 CDD:275368 8/19 (42%)
C2H2 Zn finger 156..176 CDD:275368 8/47 (17%)
COG5048 <180..341 CDD:227381 69/162 (43%)
C2H2 Zn finger 184..204 CDD:275368 8/19 (42%)
zf-H2C2_2 197..219 CDD:290200 11/21 (52%)
C2H2 Zn finger 212..232 CDD:275368 9/19 (47%)
zf-H2C2_2 224..249 CDD:290200 11/24 (46%)
C2H2 Zn finger 240..260 CDD:275368 8/19 (42%)
zf-H2C2_2 252..276 CDD:290200 11/23 (48%)
C2H2 Zn finger 268..288 CDD:275368 6/19 (32%)
C2H2 Zn finger 296..316 CDD:275368 9/19 (47%)
C2H2 Zn finger 324..341 CDD:275368 7/18 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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