DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF33B and CG12391

DIOPT Version :9

Sequence 1:	NP_001291962.1	Gene:	ZNF33B / 7582	HGNCID:	13097	Length:	785	Species:	Homo sapiens
Sequence 2:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	102/509 - (20%)
Similarity:	168/509 - (33%)	Gaps:	111/509 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    72 EQGEEPWRLEEEFPSQSFPEVWTADHLKERSQENQSKHLWEVVFINNEMLTKEQGNVIGIPFNMD 136
            |.||..: |:.|.|.:...|....:...|..||:.:|...:      |...|:.       |:.:
  Fly    71 EMGEAEY-LDGEMPQEDESETPQTEKANEGCQESSNKKDLQ------ESAAKDD-------FSKE 121

Human   137 VSSFPSRKMFCQYDSRGMSFNTVSELVISKINYL--------GKKSDEFNACGKLLLNIKHDETH 193
            .|.....|            :|..|   .|..:|        .|..||.:|..:..:....||..
  Fly   122 KSGEDGEK------------DTDKE---KKATHLHEDNNDDAEKDGDEADAEDEDDVEKPEDEDG 171

Human   194 TREKNEVL-KNRNTLSHRENTLQHEKIQTLDHNFEYSICQE----------TLLEKAVFNTRKRE 247
            |.|.:|.: ::.:.|...|:  .:|:::.::.:||.....|          .|.:..:...:|.|
  Fly   172 TEEGDEAIEEDEDALDEDED--PNEEVEEIEPDFETGTDAEGELITGDEPGDLADVPIRERKKEE 234

Human   248 NAEENNCDYNEFGRTFCDSSS----LLFHQIPPSKDSHYEFSDCEKFLCVKSTLSKHDGVPVKHY 308
            ..:|:.|       ..|.|..    |...||..:.      :|....:|...::...|.:|  .:
  Fly   235 PVDEDQC-------RVCTSKEELVCLFKKQIDATP------ADMLLVICPNVSILPKDFMP--QF 284

Human   309 DCGESGNNFRRKLCLSQLQKGDKGEKHFEC--NECGKAFWEKSHLTRHQRVH------------- 358
            .|.:         |:..|....:..|..|.  .|..|......:..|..|.:
  Fly   285 ICTK---------CMGSLTIAIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSED 340

Human   359 -------------TGEKHFQCNQCGKTFWEKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLH 410
                         .|......:.......||.......|....:||.:...........:....:
  Fly   341 EDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGRPRKKPLKRGTDSDGEPSSAQKKKY 405

Human   411 QRTHTGE-KPYQCNACGKTFYQKSDLTKHQRTHTGQKPYECYECGKSFCMNSHLTVHQRTHTGEK 474
            |.:.|.. .|::|..|..||.:|.....|::||. :..:.|..|||.|.:......|.:.|..|:
  Fly   406 QPSSTASVGPFECPNCDLTFSRKQSYVLHRKTHE-RIEHACPICGKKFKVEWAYKTHMQRHEQER 469

Human   475 P-FECLECGKSFCQKSHLTQH--QRTHIGDKPYECNACGKTFYHKSVLTRHQII 525
            . |.|..|.|.|..::.|..|  ||.......|||..|.:||..:..|.|||.:
  Fly   470 AHFRCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF33B	NP_001291962.1	KRAB	19..78	CDD:214630	3/5 (60%)
		KRAB	19..58	CDD:279668
		C2H2 Zn finger	310..330	CDD:275368	3/19 (16%)
		COG5048	336..681	CDD:227381	49/222 (22%)
		C2H2 Zn finger	338..358	CDD:275368	4/21 (19%)
		zf-H2C2_2	350..374	CDD:290200	3/49 (6%)
		C2H2 Zn finger	366..386	CDD:275368	3/19 (16%)
		zf-H2C2_2	378..403	CDD:290200	3/24 (13%)
		C2H2 Zn finger	394..414	CDD:275368	1/19 (5%)
		zf-H2C2_2	406..429	CDD:290200	5/23 (22%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..457	CDD:290200	7/22 (32%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		zf-H2C2_2	462..485	CDD:290200	7/23 (30%)
		zf-C2H2	476..498	CDD:278523	9/23 (39%)
		C2H2 Zn finger	478..498	CDD:275368	8/21 (38%)
		C2H2 Zn finger	506..526	CDD:275368	8/20 (40%)
		C2H2 Zn finger	534..554	CDD:275368
		zf-H2C2_2	546..571	CDD:290200
		C2H2 Zn finger	562..582	CDD:275368
		zf-H2C2_2	575..597	CDD:290200
		C2H2 Zn finger	590..610	CDD:275368
		zf-H2C2_2	602..625	CDD:290200
		C2H2 Zn finger	618..638	CDD:275368
		zf-H2C2_2	631..653	CDD:290200
		C2H2 Zn finger	646..666	CDD:275368
		zf-H2C2_2	658..681	CDD:290200
		COG5048	668..>727	CDD:227381
		C2H2 Zn finger	674..694	CDD:275368
		zf-H2C2_2	690..711	CDD:290200
		C2H2 Zn finger	702..722	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368
		zf-H2C2_2	742..767	CDD:290200
		C2H2 Zn finger	758..778	CDD:275368
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	16/96 (17%)
		zf-C2H2	416..438	CDD:278523	6/21 (29%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-C2H2	443..465	CDD:278523	6/21 (29%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..491	CDD:275368	5/16 (31%)
		C2H2 Zn finger	504..521	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000