DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF33A and CG6689

DIOPT Version :9

Sequence 1:	NP_001265106.1	Gene:	ZNF33A / 7581	HGNCID:	13096	Length:	832	Species:	Homo sapiens
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	133/594 - (22%)
Similarity:	232/594 - (39%)	Gaps:	116/594 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   113 KERSQENQSKHLWEVVFINNEMLTKEQGDVIGIPFNVDVSSFPSRKMFCQCDSCGMSFNTVSELV 177
            |||||..:::.|..      |:|.:|:..:|    :.:.:||....::            :||.|
  Fly   106 KERSQRRRNQELVA------ELLAEEEAKLI----HPEATSFEQDSVY------------LSETV 148

Human   178 ISKINYLG--KKSDEFNACGKLLLNIKHDETHTQEKNEVLKNRNT-LSHHEETLQHEKI--QTLE 237
            ..:::.|.  :|.:|...|    ....:|.|......::....|: |..|.|.:....|  :..|
  Fly   149 TMELDPLSGEEKLEELQKC----RTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDE 209

Human   238 HNFEYSICQETLLEKAVFNTQKRENAEENNCDYNEFGRTLCDSSSLLFHQISPSRDNHYEFSDCE 302
            .......| ::.|::|:              |:.|    :|.|:.|...|..||.|.
  Fly   210 PRLMCPAC-KSALDQAI--------------DFRE----MCISTELKLSQAKPSTDE-------- 247

Human   303 KFLCVKSTLSKPHGVSMKHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTR 367
                |:......:.:|..|....::.|....::       .|.|..|.|..........:..:..
  Fly   248 ----VQIEAENENPISSDHDLISDTENTNVEEI-------EDAGGDHVEDEATSDDQTSQEAVDE 301

Human   368 HQRVHTGQKPFQCNECEKAFWDKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEK 432
            .......|.|.......|.|  |..|.:    :||::.....:.....|...|    :....||:
  Fly   302 VAESPAAQDPLSVALGAKIF--KELLDQ----YTGKEKARLRKGAPIASKPKA----KEKAAGEQ 356

Human   433 PYQCNACGKTFCQKSDLTKHQRTHTGLKP--YECYECGKSFRVTSHLKVHQRTHTGEKPFECLEC 495
            ..:.:|..||   |.:....:|.....||  :.|.:||::||::.:|::|...||..|.::|.||
  Fly   357 KPKRSANPKT---KEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTEC 418

Human   496 GKSFSEKSNLTQHQRI-HIGDKSYECNACGKTFYHKSLLTRHQIIHTGWKPYECYECGKTFCLKS 559
            .|:|.:......|.|| |.|:..:.|..|.:||.:.....:|:        .|.:.......:|
  Fly   419 PKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHE--------SEVHNAAPRLIVK- 474

Human   560 DLTVHQRTHTGQKP---------FACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIFYNKS 615
                    ....||         :.|..|.|.::.|..|..|.::||....|:|..|.|.:.:.:
  Fly   475 --------RINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPN 531

Human   616 YLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGKAFCHKSALIVHQRTH 680
            .|.:|..||. ::|.:|:.|.|.|||:::|.:|:.||.||:||.|..|...|.:|    .:.::|
  Fly   532 KLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYK----YNMKSH 591

Human   681 TQEKPYKCN 689
            ...|.::.|
  Fly   592 ANSKMHQDN 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF33A	NP_001265106.1	KRAB	33..92	CDD:214630
		KRAB	33..72	CDD:279668
		COG5048	163..537	CDD:227381	78/381 (20%)
		C2H2 Zn finger	324..344	CDD:275368	1/19 (5%)
		C2H2 Zn finger	352..372	CDD:275368	0/19 (0%)
		zf-H2C2_2	364..388	CDD:290200	3/23 (13%)
		C2H2 Zn finger	380..400	CDD:275368	4/19 (21%)
		zf-H2C2_2	392..417	CDD:290200	3/24 (13%)
		C2H2 Zn finger	408..428	CDD:275368	2/19 (11%)
		zf-H2C2_2	420..443	CDD:290200	5/22 (23%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		COG5048	444..820	CDD:227381	71/258 (28%)
		zf-H2C2_2	448..471	CDD:290200	6/24 (25%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	476..500	CDD:290200	9/23 (39%)
		C2H2 Zn finger	492..512	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	548..568	CDD:275368	1/19 (5%)
		zf-H2C2_2	560..585	CDD:290200	5/33 (15%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		zf-H2C2_2	589..611	CDD:290200	8/21 (38%)
		C2H2 Zn finger	604..624	CDD:275368	5/19 (26%)
		zf-H2C2_2	616..639	CDD:290200	8/22 (36%)
		C2H2 Zn finger	632..652	CDD:275368	8/19 (42%)
		zf-H2C2_2	645..667	CDD:290200	10/21 (48%)
		C2H2 Zn finger	660..680	CDD:275368	4/19 (21%)
		zf-H2C2_2	672..695	CDD:290200	3/18 (17%)
		C2H2 Zn finger	688..708	CDD:275368	1/2 (50%)
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		zf-H2C2_2	756..781	CDD:290200
		C2H2 Zn finger	772..792	CDD:275368
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	17/95 (18%)
		zf-C2H2	385..407	CDD:278523	7/21 (33%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		zf-met	574..597	CDD:289631	6/26 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100