DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MPPED1 and CG16717

DIOPT Version :9

Sequence 1:	NP_001037835.1	Gene:	MPPED1 / 758	HGNCID:	1306	Length:	326	Species:	Homo sapiens
Sequence 2:	NP_648343.1	Gene:	CG16717 / 39129	FlyBaseID:	FBgn0036028	Length:	300	Species:	Drosophila melanogaster

Alignment Length:	300	Identity:	140/300 - (46%)
Similarity:	182/300 - (60%)	Gaps:	29/300 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    45 IEVDEYSSNPTQAFTFYNINQGRFQPPHVQMVDPVPHDAPKPPGYTRFVCVSDTHSRTDPIQ--M 107
            :.|...|.:||.|:...:..|      .|..|...|......|...|.||:|||||.|..|:  :
  Fly     3 VPVHPLSQDPTAAWREISKTQ------RVIKVTMKPPTTTVAPNKARVVCMSDTHSLTPYIKFDI 61

Human   108 PYGDVLIHAGDFTELGLPSEVKKFNEWLGSLPYEYKIVIAGNHELTFDQEFMADLIKQDFYY--- 169
            |.||:.|||||||:.|...||::||.|:|:||:.:||||||||||:||:.|.....|...:.
  Fly    62 PDGDIFIHAGDFTKCGQLEEVEEFNTWIGALPHRHKIVIAGNHELSFDRTFTHPFQKSKSHASSS 126

Human   170 ----------FPSVSKLKPENYE------NVQSLLTNCIYLQDSEVTVRGFRIYGSPWQPWFYGW 218
                      .|::...| ||.|      ||:.:||||.||:|..:.:.|.:||||||||.|..|
  Fly   127 KHTGMSILDDLPTLGNAK-ENLESAVQTQNVRDVLTNCRYLEDELLEIWGIQIYGSPWQPEFCRW 190

Human   219 GFNLPRGQALLEKWNLIPEGVDILITHGPPLGFLDWVPKKMQRVGCVELLNTVQRRVQPRLHVFG 283
            .||:|||.|.|:|||.||||:|||:||.||:|..|.....: |.||||||:|||:||:|:.||||
  Fly   191 AFNVPRGTACLDKWNQIPEGIDILVTHTPPVGHGDLCCSGV-RAGCVELLSTVQQRVRPKYHVFG 254

Human   284 HIHEGYGVMADGTTTYVNASVCTVNYQPVNPPIVIDLPTP 323
            |:|||||:.:||...:||||.|.:||.|.|.|||.|:..|
  Fly   255 HVHEGYGITSDGRIIFVNASTCDINYLPNNAPIVFDVTLP 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPPED1	NP_001037835.1	MPP_239FB	91..303	CDD:277325	118/232 (51%)
CG16717	NP_648343.1	MPP_239FB	43..274	CDD:277325	118/232 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159050
Domainoid	1	1.000	214	1.000	Domainoid score	I2732
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15012
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3118
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57786
OrthoDB	1	1.010	-	-		D1301937at2759
OrthoFinder	1	1.000	-	-		FOG0002700
OrthoInspector	1	1.000	-	-		otm41070
orthoMCL	1	0.900	-	-		OOG6_101637
Panther	1	1.100	-	-	LDO	PTHR12905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5633
SonicParanoid	1	1.000	-	-		X1798
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940