DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZSCAN20 and CG14710

DIOPT Version :9

Sequence 1:	NP_001364305.1	Gene:	ZSCAN20 / 7579	HGNCID:	13093	Length:	1043	Species:	Homo sapiens
Sequence 2:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	108/460 - (23%)
Similarity:	174/460 - (37%)	Gaps:	116/460 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   603 WGEVANEDAVKPSTLCPKAPDMGFEMRHEDEDQISEQDIFEGLPGALSKCPTEAVCQPLDWGEDS 667
            :|:....|..|...||.:       :|.....|:.|:        |.:.|     |:.:.
  Fly    26 FGDKGESDLRKKLELCCR-------IRVRQSPQLPEK--------ACNSC-----CEFVQ----- 65

Human   668 ENENEDEGQWGN------PSQEQWQESSSE--EDLEKLIDHQ-GLYLAEKPYKCDTCMKSFSRSS 723
                    .|.|      .||..|:.||||  |.|.:..|.: .|||
  Fly    66 --------MWFNFRQMCLNSQVYWETSSSERPEALAQASDAEYMLYL------------------ 104

Human   724 HFIAHQRIHTGEKPYKCLECGKNFSDRSNLNTHQRIHTGEKPYKCLECGKSFSDHSNLITHQRIH 788
                ::.:|        |:.|....::..:..   |..|::..:  :..:...|.:..|.::.|.
  Fly   105 ----YENLH--------LKLGTENQEKEEITA---IEEGDEQQE--DQSQEVLDFNGFIINESIE 152

Human   789 TGEKPYKCGECWKSFNQSSNLLKHQRIHLGGNP-DQCSEPGGNFAQSPSFSAHWRNSTE------ 846
            ..|:|       .:.:....|:.|...::.... ::..:..|...:..| :|:.....|
  Fly   153 EDEEP-------NTESPEQILISHMDSYVDDQQMEELIDDKGELVEELS-NANTFYEVEYGDEEL 209

Human   847 --ETAPEQPQSISKDLNSPG-PHSTNSGEKLYECSECGRSFSKSSALISHQRIHTGEKP------ 902
              .:||....|...|...|| |...::..|.           |...:.:.:|   |.:|
  Fly   210 LMSSAPSPHPSFKMDKQKPGRPRKPDAELKF-----------KRKDINAKER---GNQPKCKEEE 260

Human   903 -YECAECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITHQRVHTGEKPYKCLECGK 966
             :.|..||..|.|.|....|..||:..||::|..|.|.|.:..:|..|.|.|||::||||:.|.:
  Fly   261 KFMCILCGNVFYKKSVFTAHMMTHSEYKPHQCEICNKSFRQMGELRAHIRRHTGDRPYKCMYCDR 325

Human   967 FFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTGEKPYKCTECGKDFNNSSHFS 1031
            .|.|||..:.|:|:||..:||.|:||||.|..::.|..|...|:.:|.|.|..|.|.|.......
  Fly   326 HFYDRSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSHSAQKNYNCGICCKSFTLLHQLK 390

Human  1032 AHRRT 1036
            ||.:|
  Fly   391 AHLQT 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZSCAN20	NP_001364305.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		SCAN	47..132	CDD:396558
		Myb_DNA-bind_4	323..404	CDD:404682
		Myb_DNA-bind_4	483..564	CDD:404682
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	661..692		9/38 (24%)
		COG5048	699..>1029	CDD:227381	83/347 (24%)
		C2H2 Zn finger	712..732	CDD:275368	0/19 (0%)
		C2H2 Zn finger	740..760	CDD:275368	2/19 (11%)
		C2H2 Zn finger	768..788	CDD:275368	2/19 (11%)
		C2H2 Zn finger	796..816	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..873		10/46 (22%)
		C2H2 Zn finger	877..897	CDD:275368	2/19 (11%)
		C2H2 Zn finger	905..925	CDD:275368	7/19 (37%)
		C2H2 Zn finger	933..953	CDD:275368	7/19 (37%)
		C2H2 Zn finger	961..981	CDD:275368	8/19 (42%)
		C2H2 Zn finger	989..1009	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1017..1037	CDD:275368	7/20 (35%)
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071	16/89 (18%)
		COG5048	<261..395	CDD:227381	53/133 (40%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-C2H2	290..312	CDD:278523	7/21 (33%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..327	CDD:290200	11/22 (50%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..357	CDD:290200	12/21 (57%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		C2H2 Zn finger	376..395	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910