DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egfem1 and NimB2

DIOPT Version :9

Sequence 1:	XP_006535622.1	Gene:	Egfem1 / 75740	MGIID:	1922990	Length:	658	Species:	Mus musculus
Sequence 2:	NP_723857.1	Gene:	NimB2 / 260645	FlyBaseID:	FBgn0028543	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	103/393 - (26%)
Similarity:	132/393 - (33%)	Gaps:	153/393 - (38%)

- Green bases have known domain annotations that are detailed below.

Mouse    72 VCREEQLT--LVRLSRPCAQAFIDTIQFWKQG----------CSGPRWCVGYERRIRYYIIYRHV 124
            ||.:|..|  |:|.||.         ||...|          |     |.||||.       .|:
  Fly   134 VCYKEVPTASLLRNSRD---------QFVGNGTTPDMSRIQVC-----CDGYERN-------PHI 177

Mouse   125 YATEHQTVFRCCPGWIQWDDEPGCFSSLSSLGTHFSGRECSYQDTRQCLCSQGFHGPHCQYDINE 189
            |.       ||.|  |..||   |.:.:           |:..:|  |:|..|    |.:....:
  Fly   178 YR-------RCEP--ICADD---CRNGI-----------CTAPNT--CVCIPG----HVRTAEGK 213

Mouse   190 C------AVDNGGCRDRCCNTIGSYYCRCQAGQKLEEDGRG-CEDVDECAVVNGGCQ-QRCINTL 246
            |      ...||.|.:|       ..|:|:.|..||.:.|. |:  .||   ..||. .||:
  Fly   214 CISTCPLGCGNGVCDER-------NECKCREGYSLEPETRKYCQ--PEC---KPGCSFGRCV--- 263

Mouse   247 GTFHCECDTGYRRHADERTCIISFLSETDPCAGANGCAHLCQT-ENGM----ARCACHAGYQLSE 306
            ....|.|..|||..||                  ..|..:|.: |||.    ..|.|:|||...:
  Fly   264 APNKCACLDGYRLAAD------------------GSCEPVCDSCENGKCTAPGHCNCNAGYLKLQ 310

Mouse   307 DKKACEDINECAEELAPCAHHCVNSK--GSFTCTCHPGFELGADRKHCYRIELEIVNICEKN--N 367
            .:  ||.|         |:..|.|.:  |...|.|..|||.  |||     ..|.:..|:..  |
  Fly   311 GR--CEPI---------CSIPCKNGRCIGPDICECASGFEW--DRK-----SAECLPKCDLPCLN 357

Mouse   368 GGCSHHCEPAIGGAHCSCNHGHQLDTDGKTCIDFDECESGEACCAQLCINYLGGY-----ECSCE 427
            |.|       :|...|.|..|:..|...:..     |:..   |.|.|.|   ||     .|.|.
  Fly   358 GVC-------VGNNQCDCKTGYVRDEHQRNI-----CQPH---CPQGCQN---GYCSAPNFCICR 404

Mouse   428 EGF 430
            .||
  Fly   405 PGF 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfem1	XP_006535622.1	EMI	71..140	CDD:369419	22/79 (28%)
		FXa_inhibition	190..225	CDD:373209	11/41 (27%)
		vWFA	<213..265	CDD:381780	18/53 (34%)
		vWFA	<268..310	CDD:381780	10/46 (22%)
		vWFA	<308..350	CDD:381780	13/43 (30%)
		FXa_inhibition	363..398	CDD:373209	9/36 (25%)
		vWFA	<395..436	CDD:381780	11/41 (27%)
NimB2	NP_723857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900