Protein Alignment Eif4b and eIF4B

DIOPT Version :9

• Sequence 1: NP_663600.2
• Gene: Eif4b / 75705
• MGIID: 95304
• Length: 611
• Species: Mus musculus
• Sequence 2: NP_001015319.1
• Gene: eIF4B / 3355041
• FlyBaseID: FBgn0020660
• Length: 459
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 149/536 - (27%)
• Similarity: 224/536 - (41%)
• Gaps: 134/536 - (25%)

Mouse     1 MAASAKK-KNKKGKTISLTDFLAEDGGTGGGSTYVPKPVSWADETDDLEGDVSTTWHSNDDDVYR 64
            ||::.|| |..||..|||..||. :.....|:|.|.|.:.      :|:||      .:||....
  Fly     1 MASAGKKGKKNKGTVISLQSFLC-NSDAPVGTTQVSKKIR------NLDGD------DSDDGSGT 52

Mouse    65 APPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEDSIKDFFRGLNISAVRLPRE 129
            .|.:.:  |||||||.|  ..|.:.:|...|:.|::.|||:|..||.:.:||.|:|:.::|||||
  Fly    53 LPLVYQ--LPTAPRANR--IFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLISLRLPRE 113

Mouse   130 PSNPDRLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQ--AQDKDRDDRSFGRDRNRDS 192
            .....|.:||||.|.|:.:.|:..|||.:.|:..||||::::::  .|.:.:.:|.|....|...
  Fly   114 DGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNGD 178

Mouse   193 DKTDTDWRARPTTDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDR 257
            ::...:|              ||...:.|..:           ||...:.....|:......||.
  Fly   179 NRDSGNW--------------RRDSQNNGSNF-----------GYSSNFERSFNRERKSLPDRDD 218

Mouse   258 YDDRGS-RDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDY 321
            .:..|| |...|.........||..   .:..:.||.|..:..|||         ||::.|:.:
  Fly   219 VNTPGSWRTSARPQSIDTSPTRREV---EQVSEKYREGRVKIADRY---------SREETSKVE- 270

Mouse   322 RRDDRGPPQRPRLNLKPRSAPKED----------------DASASTSQSSRAASIFGGAKPVDTA 370
                   .:||:||||||:.|..|                |....||    :.::||.|||||||
  Fly   271 -------EERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTS----SLNVFGSAKPVDTA 324

Mouse   371 AREREVEER--LQKEQEK------LQRQLDEPKLDRRPRE---RHPSWRS--------------- 409
            |||.|:|:|  |.::|:|      |..:|.|.::|:...|   ...|||:
  Fly   325 ARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKNDNESLSATVSWRTNQDYKESDKINKCPG 389

Mouse   410 EETQERERSRTGSESSQTGASATSGRNTRRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVM 474
            |:.::.|..|......|          ..|.|..:...|.....:.||.:..|...|..|
  Fly   390 EKQRDEEIHRLNHARGQ----------FNRPELLREKPNANGESKRDCRNDRSVSKKTSQ----- 439

Mouse   475 PAPPPKENAWVKRSSN 490
                   |..|.:|||
  Fly   440 -------NDLVLQSSN 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eif4b	NP_663600.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		32/92 (35%)
		RRM	<83..256	CDD:223796	46/174 (26%)
		RRM_eIF4B	95..171	CDD:240848	33/75 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..611		84/363 (23%)
		DUF1777	225..>290	CDD:285811	11/65 (17%)
eIF4B	NP_001015319.1	RRM	<72..268	CDD:223796	61/232 (26%)
		RRM_eIF4B	79..155	CDD:240848	33/75 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849450
Domainoid	1	1.000	72	1.000	Domainoid score	I9349
eggNOG	1	0.900	-	-		E33208_3BDSB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4365
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58965
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	1	1.000	-	-		FOG0007285
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105219
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.700