DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF18 and CG17802

DIOPT Version :9

Sequence 1:	NP_001290210.1	Gene:	ZNF18 / 7566	HGNCID:	12969	Length:	549	Species:	Homo sapiens
Sequence 2:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	89/398 - (22%)
Similarity:	153/398 - (38%)	Gaps:	103/398 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   202 LEERLIRDQDLGASLLPAAPQEQWRQLDSTQKEQYWDLMLET--------------YGKMVSGAG 252
            ::.|.:..:|.|....|.:...:..:::..:.||  :::.|.              |.|....:.
  Fly    76 IQRRSVEAKDDGCWADPLSDAHEGLKINDAEVEQ--EVLYEVSYADNEGLEEDHDLYKKEEEESE 138

Human   253 ISHPK--SDLTNSIEFGEELAGIYLHVNEKIPRPTCIGDRQENDKENLNLENHRDQELLHASCQA 315
            ::..|  .|:...|.|.:|                  .|.||..:|   .|:..|::..|...:.
  Fly   139 VNENKEFEDIACEIPFSKE------------------DDEQEQQQE---YEDMVDKKTGHDDGEE 182

Human   316 SGEVPSQASLRGFFTEDEPGCFGEGENLPEALQNIQDEGTGEQLSPQERISEKQLGQHLPNPHSG 380
            |.|.          .|.:|       :..|:.||.:||...::       .:.:|.|:.......
  Fly   183 SQEC----------EESQP-------DEEESQQNEEDEEESQE-------DDDELWQNEDGDSDT 223

Human   381 EMSTM----------WLEE----KRETSQKGQP---------------RAPMAQKLPTCRECGKT 416
            :..:|          .|:|    :|:.:::..|               :..::||:..|..|||.
  Fly   224 DADSMSDIEATSRQSALDEDKKPRRKYTKRSSPKNDDTDFLKPAKKKRKTYISQKVHICDHCGKK 288

Human   417 FYRNSQLIFHQRTHTGETYFQCTIC-KKAFLRSSDFVKHQRTHTGEKPCKCDYCGKGF-SDFSGL 479
            |........|...|:|...|:|..| :|.|.|....:..:..|.||||..|.:|.:.| ......
  Fly   289 FTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNIHIRVKHRGEKPYACQFCDERFVHSTMRS 353

Human   480 RHHEKIHTGEKP---YKCPICEKSFIQRSNFNR--HQRVHTGEKPYKCSHCGKSFSWSSSLDKHQ 539
            ||..::|..:|.   :||..|:|.:  .||:.|  |:.|||||:.:.|..|..||:.:|:|..|.
  Fly   354 RHENRVHRNKKTPKNFKCNYCDKRY--ESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHY 416

Human   540 RS--HLGK 545
            ||  |..|
  Fly   417 RSRQHQNK 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF18	NP_001290210.1	SCAN	37..148	CDD:322011
		KRAB	<222..249	CDD:307490	5/40 (13%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		COG5048	<436..549	CDD:227381	42/119 (35%)
		C2H2 Zn finger	438..458	CDD:275368	5/20 (25%)
		C2H2 Zn finger	466..486	CDD:275368	5/20 (25%)
		zf-H2C2_2	479..503	CDD:316026	8/26 (31%)
		C2H2 Zn finger	494..514	CDD:275368	7/21 (33%)
		zf-H2C2_2	506..530	CDD:316026	11/25 (44%)
		C2H2 Zn finger	522..542	CDD:275368	9/21 (43%)
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	5/20 (25%)
		C2H2 Zn finger	339..360	CDD:275368	5/20 (25%)
		C2H2 Zn finger	371..388	CDD:275370	6/18 (33%)
		zf-met	398..421	CDD:289631	9/22 (41%)
		C2H2 Zn finger	399..417	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960