Protein Alignment ZNF708 and CG5245

DIOPT Version :10

• Sequence 1: NP_067092.2
• Gene: ZNF708 / 7562
• HGNCID: 12945
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 181/508 - (35%)
• Similarity: 264/508 - (51%)
• Gaps: 47/508 - (9%)

Human    64 NMKRHEMAAKPPAMCSHFAKDLRPEQ--YIKNS-FQQV--ILRRYGKCGYQKGCKSVDEHKLHKG 123
            |:.:..:..:||      .:|...|:  :|.|| |:::  .::....|.|.|..:.|
  Fly     5 NVDQRPVKDEPP------QEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPV-------- 55

Human   124 GHKGLNRCVTTTQSKIVQCDKYVKVFHKYSNAKRHKIRHTGKNPFKCKECGKSFCMLSQLTQHEI 188
              ||:...:.|.:|||               ||:..:|.. .:.|||.:|.|:|.....|..|..
  Fly    56 --KGVPSKLKTCKSKI---------------AKKRPLRKQ-TDTFKCTQCQKTFTRKENLESHLR 102

Human   189 IHTGEKPYKCEECGKAFKKSSNLTNHKIIHTGEKPYKCEECGKAFNQSSTLTRHKIIHTGEKLYK 253
            :|..|:|::|..|.|:|.:.::...|.:.|. ::|:||..|.|.|.|:|:|.:|...||||:.:|
  Fly   103 LHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFK 166

Human   254 CEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSSNLTNHKKIHTGEKPYKCGECGKAFT 318
            |.:|..:|.|.|:|..|...|:.|:|::|..|.||||.:|:|..|.:.|...:|:||..|.|:|.
  Fly   167 CTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFK 231

Human   319 LSS----HLTTHKRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHL 379
            |.|    ||.||     .|:.:||.:|.|.|....:|..|..:|..|.|:||..|.:.|.|:|.|
  Fly   232 LRSILQKHLLTH-----AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRL 291

Human   380 TNHKVIHTGEKPYKCEECGKAFTKSSTLTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTE 444
            ..|.:.|.|::|.||.:|...|...|....|..:||.::.|||.||.|:|...|.|.:|:.:||.
  Fly   292 QLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTG 356

Human   445 DKPYKCEECGKTFNYSSNFTNHKKIHTGEKPYKCEECGKSFILSSHLTTHKIIHTGEKPYKCKEC 509
            ::|:||..|.|.|...::...|...|.|||..||..|.|.|.|||.|..|...|||:..::|..|
  Fly   357 ERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHC 421

Human   510 GKAFNQSSTLMKHKIIHTGEKPYKCEECGKAFNQSPNLTKHKRIHTKEKPYKC 562
            .|::..||||..|...||||.|:||..|.|.|.:|....:|.|.||.||||||
  Fly   422 SKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKC 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF708	NP_067092.2	KRAB	4..64	CDD:214630	181/508 (36%)
		zf-H2C2_2	156..177	CDD:463886	7/20 (35%)
		C2H2 Zn finger	170..190	CDD:275368	6/19 (32%)
		zf-H2C2_2	183..207	CDD:463886	9/23 (39%)
		C2H2 Zn finger	198..218	CDD:275368	5/19 (26%)
		zf-H2C2_2	210..235	CDD:463886	8/24 (33%)
		C2H2 Zn finger	226..246	CDD:275368	8/19 (42%)
		COG5048	250..>563	CDD:227381	128/317 (40%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		C2H2 Zn finger	282..302	CDD:275368	9/19 (47%)
		C2H2 Zn finger	310..330	CDD:275368	10/23 (43%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	422..442	CDD:275368	8/19 (42%)
		C2H2 Zn finger	450..470	CDD:275368	5/19 (26%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		C2H2 Zn finger	506..526	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	160/408 (39%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	1/1 (100%)