DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF14 and CG11247

DIOPT Version :9

Sequence 1:	NP_066358.2	Gene:	ZNF14 / 7561	HGNCID:	12924	Length:	642	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	131/437 - (29%)
Similarity:	196/437 - (44%)	Gaps:	59/437 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   200 KQCGKTFIYYQ-SFQKHAHTG----KKPYECKQCGKAFICYQSFQRHKRTHTGEKPYECKQCGKA 259
            :|..|...|.| ..:|.|..|    :|.:.|.||.|.|......|||...|:.|:|::||.|||:
  Fly    65 EQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKS 129

Human   260 FSCPTYFRTHERT-HTGEKPYKCKECGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFR 323
            :......:.|..| |...|.:.|.:|.|:|:.....|.|.|.|||||||.|..|.|.|......:
  Fly   130 YRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQ 194

Human   324 AHVIIH--TGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSISLRLH-ERTH 385
            .|::.|  |..:.:.|.:|..:|:::.:.|||...|.....:.|..|...|:..::||.| .:.|
  Fly   195 QHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEH 259

Human   386 TGEKPYECKQCHKTFSFSSSLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERTHNAEKPYECK 450
            .....:||:.|||..                :|.|            .|..|.:.|.|.|.:.|:
  Fly   260 HKLTQFECEICHKMI----------------EPDE------------DLATHMQRHTAVKTHVCE 296

Human   451 QCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIRSSSFRLHERTHTGEKPYECKLCGKTFSFS 515
            .|...|...|.:.:|.|.||||:||:|:.|.:.|..||..:||.|.||||||:.|:||....:||
  Fly   297 VCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFS 361

Human   516 --SSLREH-EKIHTGNKPFECKQCGKAFLRSSQIRLHERTHT---------GEKPYQCKQCGKAF 568
              :.|:.| :|||...||:.|:.|...|    :|::..::|.         |:||...:......
  Fly   362 QLAHLKNHMKKIHKQQKPYMCEGCHDFF----KIKVELQSHVEHCAKCPVDGDKPSGNQSEDAQI 422

Human   569 ISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRI------HERSH 609
            :|..:|.|...........:.:|.|...|...:|.|      ..:||
  Fly   423 LSVLRFNMAVVLKKISSAQKLRQLGYEKRLIDNVIIASLKLAQRQSH 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF14	NP_066358.2	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	80..97	CDD:275368
		C2H2 Zn finger	105..125	CDD:275368
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368
		C2H2 Zn finger	199..217	CDD:275368	5/17 (29%)
		C2H2 Zn finger	225..245	CDD:275368	8/19 (42%)
		zf-H2C2_2	237..262	CDD:290200	11/24 (46%)
		COG5048	249..633	CDD:227381	113/383 (30%)
		C2H2 Zn finger	253..273	CDD:275368	7/20 (35%)
		zf-H2C2_2	265..289	CDD:290200	7/24 (29%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..316	CDD:290200	13/22 (59%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		C2H2 Zn finger	365..385	CDD:275368	6/20 (30%)
		zf-H2C2_2	377..401	CDD:290200	9/24 (38%)
		C2H2 Zn finger	393..413	CDD:275368	4/19 (21%)
		zf-H2C2_2	405..429	CDD:290200	2/23 (9%)
		C2H2 Zn finger	421..441	CDD:275368	2/19 (11%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		zf-H2C2_2	461..486	CDD:290200	11/24 (46%)
		C2H2 Zn finger	477..497	CDD:275368	8/19 (42%)
		C2H2 Zn finger	505..525	CDD:275368	8/22 (36%)
		zf-H2C2_2	517..542	CDD:290200	10/25 (40%)
		C2H2 Zn finger	533..553	CDD:275368	4/19 (21%)
		C2H2 Zn finger	561..581	CDD:275368	3/19 (16%)
		zf-H2C2_2	574..596	CDD:290200	4/21 (19%)
		C2H2 Zn finger	589..609	CDD:275368	5/25 (20%)
		zf-H2C2_2	601..626	CDD:290200	4/15 (27%)
		C2H2 Zn finger	617..637	CDD:275368
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/158 (33%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	<192..369	CDD:227381	61/204 (30%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	8/47 (17%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000