DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF7 and CG6654

DIOPT Version :9

Sequence 1:	NP_001336738.1	Gene:	ZNF7 / 7553	HGNCID:	13139	Length:	707	Species:	Homo sapiens
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	165/592 - (27%)
Similarity:	230/592 - (38%)	Gaps:	138/592 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   102 KTDSTIRTENEQACEDMDILKSESYGTVVRISPQ-DFPQNPGFGDVSDSEVWLDSHLGSPGLKVT 165
            :||:...|:.||   :..::||       .||.. |:   .|.|:|.|.|:     ...|..|.|
  Fly   120 QTDAVTTTDAEQ---NTSLIKS-------TISVDLDY---EGEGEVFDYEL-----PDEPVEKTT 166

Human   166 GFTF--QNNCLNEETVVPKTFTKDAPQGCKELGSSGLDCQPLESQGESAEGMSQRCEECG----K 224
            ....  |.|..:|:.||   ||:                ..:..:|:..| :.|:..||.    :
  Fly   167 SLILQVQGNLKDEKEVV---FTQ----------------TNVIYEGDDHE-LEQQIRECNLAIFE 211

Human   225 GIRATSDIALHWEINTQKISRCQECQKKLSDCLQGKH------------------------TNNC 265
            |:...::|.   .:...:::..:...|.|:.....||                        |:..
  Fly   212 GVDNEAEII---TVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRR 273

Human   266 HG--------EKPYECAECGKVFRLCSQLN-QHQRIHTGEKPFKCTECGKAFRLSSKLIQHQRIH 321
            .|        ..|.:.....|..||.:|.. ...|..|...|  .|..|.|             .
  Fly   274 RGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGP--STTSGAA-------------T 323

Human   322 TGEKPYRCEECGKAFGQSSSLIHHQRIHTG--ERPYGCRECGKAFSQQSQLVRHQRTHTGERPYP 384
            |.|..|.|:.|...|....||:.|:| ..|  .|.|.|.||.|.|.....|..||.:|..   :.
  Fly   324 TPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HN 384

Human   385 CKECGKAFSQSSTLAQHQRMHTGEKAQILKASDSPSLVAHQRIHAVEKPFKCDECGKAFRWISRL 449
            |.|||........|::|  |..|.|..:..                    :|:.|.|.|..:|.|
  Fly   385 CPECGIRCDSKEALSKH--MVQGHKRNLRN--------------------QCNICQKVFTMLSTL 427

Human   450 SQHQLIHTGEKPYKCNKCTKAFGCSSRLIRHQRTHTGEKPFKCDECGKGFVQGSHLIQHQRIHTG 514
            ..|..|||||||:.||.|.|:|..::.|.:|:..|:..|.|||:.|...||..:.|..|.|.|||
  Fly   428 RDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTG 492

Human   515 EKPYVCNDCGKAFSQSSSLIYHQRIHKGEKPYECLQCGKAFSMSTQLTIHQRVHTGERPYKCNEC 579
            :||:.|..|...|:.|.||..|:|.|.||:||.|..|...|:....|..|:|.|||||||.|..|
  Fly   493 DKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFC 557

Human   580 GKAFSQNSTLFQHQIIHAGVKPYECSECGKAF----SRSSYLIEHQRIHTRAQWFYEYGNALEGS 640
            .|.|:|......||..|.|.:.|.|..|.:.|    ...|:|..|::...|...|
  Fly   558 SKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQHDKRLVHF---------- 612

Human   641 TFVSRKK 647
            ||:|.|:
  Fly   613 TFLSNKE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF7	NP_001336738.1	KRAB	25..86	CDD:214630
		PHA02693	64..>137	CDD:333460	9/35 (26%)
		COG5048	239..696	CDD:227381	133/448 (30%)
		C2H2 Zn finger	246..265	CDD:275368	5/42 (12%)
		C2H2 Zn finger	273..293	CDD:275368	5/20 (25%)
		C2H2 Zn finger	301..321	CDD:275368	3/19 (16%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	6/23 (26%)
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	87/237 (37%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	7/22 (32%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	18/47 (38%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000