DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZIC2 and iec1

DIOPT Version :9

Sequence 1:	NP_009060.2	Gene:	ZIC2 / 7546	HGNCID:	12873	Length:	532	Species:	Homo sapiens
Sequence 2:	NP_594663.1	Gene:	iec1 / 2542854	PomBaseID:	SPAC144.02	Length:	249	Species:	Schizosaccharomyces pombe

Alignment Length:	120	Identity:	39/120 - (32%)
Similarity:	58/120 - (48%)	Gaps:	27/120 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   253 KQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVS----------------VEHVGGPEQSNHV 301
            :.|.||.|          :||.:...|:..||.|:.                ::|:|. .:..:.
pombe    21 ESETICHW----------QSCEQDLLTLDNLVHHIHNGTTSNLRLISNINSILDHIGN-RRPKYT 74

Human   302 CFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRT 356
            |.|::|||:|....:::.||.|:|.|||||||.|..|.|.:.|.||:.|..|.||
pombe    75 CEWDDCPRKGMVQTSRFALVAHLRSHTGEKPFICSVPECDRSFTRSDALAKHMRT 129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZIC2	NP_009060.2	Necessary for interaction with MDFIC and transcriptional activation or repression. /evidence=ECO:0000250	100..255		0/1 (0%)
		zf_ZIC	250..295	CDD:408166	12/57 (21%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		SFP1	<329..413	CDD:227516	15/28 (54%)
		C2H2 Zn finger	335..357	CDD:275368	10/22 (45%)
		C2H2 Zn finger	365..387	CDD:275368
		C2H2 Zn finger	395..415	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..452
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..532
iec1	NP_594663.1	COG5048	1..>249	CDD:227381	39/120 (33%)
		zf-H2C2_2	92..119	CDD:290200	15/26 (58%)
		C2H2 Zn finger	108..129	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910