Protein Alignment ZIC1 and CG11902

DIOPT Version :10

• Sequence 1: NP_003403.2
• Gene: ZIC1 / 7545
• HGNCID: 12872
• Length: 447
• Species: Homo sapiens
• Sequence 2: NP_651389.3
• Gene: CG11902 / 43070
• FlyBaseID: FBgn0028647
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 169
• Identity: 55/169 - (32%)
• Similarity: 82/169 - (48%)
• Gaps: 32/169 - (18%)

Human   242 CNKTFSTMHELVTHVTVEHVGGP-----------------EQSNHICFWEECPREGKPFKAKYKL 289
            |.:.::....|..|:...|  ||                 |....:|.:  |   ||...:...|
  Fly  1227 CTRKYNRKDRLTAHLKKFH--GPDCKPSTAKTPNRPISPKEPKRFLCAF--C---GKAVSSSSNL 1284

Human   290 VNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMH 354
            :.|:|.|||||||.|.:  |...|.||.:|:.|:||||||:|..|..  |.:.||.|...::||.
  Fly  1285 IIHMRRHTGEKPFKCEY--CTMAFPRSSDLQCHRRTHTGERPHVCTV--CQKGFARSYKLQQHMR 1345

Human   355 VHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQP 393
            :|:.::||.|..|:||:|..:.|..|::.|    .|.:|
  Fly  1346 IHSGERPYKCTYCEKSFTQSNDLTLHIRRH----TGERP 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZIC1	NP_003403.2	zf_ZIC	219..264	CDD:436441	4/21 (19%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		SFP1	<298..382	CDD:227516	36/83 (43%)
		C2H2 Zn finger	304..326	CDD:275368	8/21 (38%)
		C2H2 Zn finger	334..356	CDD:275368	7/21 (33%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..431		5/19 (26%)
CG11902	NP_651389.3	zf-AD	6..83	CDD:462262
		C2H2 Zn finger	208..228	CDD:275370
		C2H2 Zn finger	236..256	CDD:275370
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368
		C2H2 Zn finger	610..629	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		SUF4-like	673..>726	CDD:411020
		C2H2 Zn finger	676..703	CDD:411020
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	706..726	CDD:411020
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	762..782	CDD:275368
		C2H2 Zn finger	866..887	CDD:275368
		C2H2 Zn finger	896..918	CDD:275368
		C2H2 Zn finger	926..947	CDD:275368
		C2H2 Zn finger	967..987	CDD:275368
		C2H2 Zn finger	996..1016	CDD:275368
		C2H2 Zn finger	1044..1063	CDD:275368
		C2H2 Zn finger	1224..1244	CDD:275368	3/16 (19%)
		C2H2 Zn finger	1271..1291	CDD:275368	7/24 (29%)
		zf-H2C2_2	1283..1306	CDD:463886	12/24 (50%)
		C2H2 Zn finger	1299..1319	CDD:275368	8/21 (38%)
		C2H2 Zn finger	1327..1347	CDD:275368	7/21 (33%)
		zf-H2C2_2	1340..1364	CDD:463886	9/23 (39%)
		SFP1	<1349..1405	CDD:227516	12/36 (33%)
		C2H2 Zn finger	1355..1375	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1383..1401	CDD:275368