Protein Alignment ZIC1 and phol

DIOPT Version :10

• Sequence 1: NP_003403.2
• Gene: ZIC1 / 7545
• HGNCID: 12872
• Length: 447
• Species: Homo sapiens
• Sequence 2: NP_648317.1
• Gene: phol / 39095
• FlyBaseID: FBgn0035997
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 241
• Identity: 75/241 - (31%)
• Similarity: 105/241 - (43%)
• Gaps: 58/241 - (24%)

Human   144 PGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHH 208
            |.|.:....::|.||     ||..:|:.       .:||  :.:..||.|:....|....:|:.:
  Fly   411 PALPKLVLQNSSTNV-----RLKSAGNQ-------SKVT--KRQLTAAAQVATPNPPPPLVASSN 461

Human   209 GAGAFFRYMRQPIKQELICKWIEPEQLAN-------------------PK-----KSCNKTFSTM 249
            .|        :|.:..::.|.  |..:||                   ||     :.|||.|...
  Fly   462 PA--------RPQRPTIVTKL--PTAVANQTAGNAMGAAGAAGEEDEEPKFRCTHRGCNKEFRNH 516

Human   250 HELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFA 314
            ..:..|:   |..||.  .|:|  ..|   ||.|....||..|..||||||||.|.|.||||.|:
  Fly   517 SAMRKHM---HTHGPR--GHVC--NVC---GKSFVESSKLKRHQLVHTGEKPFECTFEGCGKRFS 571

Human   315 RSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDK 360
            ...||:.|.|.|||::|:.|..:||.:.||.|::.|.||..||..|
  Fly   572 LDFNLRTHVRIHTGDRPYHCPIDGCSKCFAQSTNLKSHMLTHTKPK 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZIC1	NP_003403.2	zf_ZIC	219..264	CDD:436441	13/68 (19%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		SFP1	<298..382	CDD:227516	32/63 (51%)
		C2H2 Zn finger	304..326	CDD:275368	11/21 (52%)
		C2H2 Zn finger	334..356	CDD:275368	9/21 (43%)
		C2H2 Zn finger	364..384	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..431
phol	NP_648317.1	COG5048	<504..614	CDD:227381	49/119 (41%)
		C2H2 Zn finger	504..526	CDD:275368	6/24 (25%)
		C2H2 Zn finger	533..553	CDD:275368	8/24 (33%)
		C2H2 Zn finger	561..583	CDD:275368	11/21 (52%)
		C2H2 Zn finger	591..613	CDD:275368	9/21 (43%)