DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ZFY and Lime

DIOPT Version :9

Sequence 1:NP_001356631.1 Gene:ZFY / 7544 HGNCID:12870 Length:801 Species:Homo sapiens
Sequence 2:NP_610529.1 Gene:Lime / 36023 FlyBaseID:FBgn0033458 Length:487 Species:Drosophila melanogaster


Alignment Length:363 Identity:69/363 - (19%)
Similarity:121/363 - (33%) Gaps:90/363 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   413 PDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTNKKISLHNHLESHKLT 477
            |:|..|.| ||.:|.:.|......|.|:..|.                  .:|:..|:..:.:.|
  Fly    72 PEGTVLCV-PCYLCKQPFNDIESFKEHLTQHA------------------AEINAWNNTRAQEQT 117

Human   478 SKAEKAIECDECGKHFSHA--GALFTHKMVHKE----KGANKMHKCKF-CE-----YETAEQGLL 530
            .............|.|.|.  ..|| |.:.|.:    ..|:..::.:| |.     |....:..:
  Fly   118 PPPTITPFVQSMNKPFVHPTDQHLF-HSIDHGDMDHHHNAHYRNRMEFGCPPPMDFYSPPLEPEI 181

Human   531 NRHLLAVHSK--NFP-------HICVECGKGF--RHPSELRKHMRIHTGEKPYQCQYCEYRSADS 584
            ...:.|||..  ..|       |...|....|  ..|.|||:.:.: :.:.|.:.......||..
  Fly   182 PFQMPAVHQHPIQIPPMYMTAQHTAYEPPVQFLGHRPLELRQKLPM-SPQSPLEPSGHPMASAIP 245

Human   585 SNLKTHIKTKHSKEMPFKCDIC----LLTFSDTKEVQQHTLVHQE--------SKTHQCLHCDHK 637
            ||..|.::.:         ::|    :||..:...|.::.....:        .|:...:..:.|
  Fly   246 SNQHTSLEMQ---------NLCVPEGILTRVEEPPVLENPRPQAQDPIQDAGAGKSRSAVLIEPK 301

Human   638 SSNSSDLKRHVISVHTKDYPHKCEMCEKGFHRPSELKKHVA-VHKGKKMHQCRHCDFKIADPFVL 701
            ..|:.       |:.......:|..|.|.......||.|.: .|..|::...|           |
  Fly   302 PPNAK-------SLAFNQGQFECNWCGKRLSSRQSLKYHESHFHGNKELAVNR-----------L 348

Human   702 SRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSG 739
            .:::...|      :|..|:|.::::..|..|||...|
  Fly   349 EKNLTKQH------KCLTCKKRYKRRTFLLMHMKVKHG 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZFYNP_001356631.1 Zfx_Zfy_act 71..406 CDD:309717
COG5048 <417..592 CDD:227381 40/197 (20%)
C2H2 Zn finger 423..443 CDD:275368 5/19 (26%)
C2H2 Zn finger 454..478 CDD:275368 2/23 (9%)
C2H2 Zn finger 486..506 CDD:275368 6/21 (29%)
COG5048 539..>676 CDD:227381 27/159 (17%)
C2H2 Zn finger 546..566 CDD:275368 6/21 (29%)
zf-H2C2_2 558..582 CDD:338759 4/23 (17%)
C2H2 Zn finger 574..593 CDD:275368 5/18 (28%)
C2H2 Zn finger 603..652 CDD:275368 8/60 (13%)
C2H2 Zn finger 660..680 CDD:275368 6/20 (30%)
zf-C2H2 715..737 CDD:333835 7/21 (33%)
C2H2 Zn finger 717..737 CDD:275368 7/19 (37%)
zf-H2C2_2 729..753 CDD:338759 5/11 (45%)
C2H2 Zn finger 745..766 CDD:275368
C2H2 Zn finger 774..794 CDD:275368
LimeNP_610529.1 C2H2 Zn finger 317..336 CDD:275368 6/18 (33%)
C2H2 Zn finger 358..377 CDD:275368 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24408
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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