DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZBTB14 and CG10321

DIOPT Version :9

Sequence 1:	NP_001137295.1	Gene:	ZBTB14 / 7541	HGNCID:	12860	Length:	449	Species:	Homo sapiens
Sequence 2:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	309	Identity:	76/309 - (24%)
Similarity:	125/309 - (40%)	Gaps:	71/309 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   160 DDDVEEIGDQDD----SPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGS------EEVRKVN 214
            |.|.|.||::.|    ...||.:|.:.....||:   |::.:.:|.:....|      ||::.::
  Fly   451 DQDCEYIGEEQDPHLSGDVDDDLEYSIMEPPDGE---TSVDIDQAFMDSEQSHHQQHQEEMQSIS 512

Human   215 CYGQEVE--------------------SMETPE-SKDLGSQTPQALTFNDGMSEVKDEQTP--GW 256
            .....||                    :..||: :|....|.|..:|.     |..|.|.|  |.
  Fly   513 LENAVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQIPAGVTL-----EPCDHQPPAAGS 572

Human   257 TTAASDMKFEYLLYGHHRE------QIACQACGKTFSDEGRL-----RKHEKLHTADRPFVCEMC 310
            ||::.      |...:.|:      .||.......:..:..|     |:|.....:.| ::|.:|
  Fly   573 TTSSK------LAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFIRQHTSPLGSGR-YICHLC 630

Human   311 TKGFTTQAHLKEHLKIHTGY------KPYSCEVCGKSFIRAPDLKKHERVHSNE--RPFACHMCD 367
            :..|.....|:.|:..||.:      |...|::|.|||.....|:.|.:.|..|  .|. |.:|:
  Fly   631 STEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPM-CTICN 694

Human   368 KAFKHKSHLKDHERRHRGEKPFVCG--SCTKAFAKASDLKRHENNMHSE 414
            :.||.|:.|..|.:.|: ::.:.||  :|.|.|:.|.:||.|....|.|
  Fly   695 RTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKHPE 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB14	NP_001137295.1	BTB_POZ_ZBTB14	18..131	CDD:349513
		Nuclear localization signal. /evidence=ECO:0000255	50..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..194		11/37 (30%)
		C2H2 Zn finger	279..299	CDD:275368	3/24 (13%)
		SFP1	<303..383	CDD:227516	26/87 (30%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..344	CDD:404364	10/30 (33%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..407	CDD:275368	8/17 (47%)
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	16/67 (24%)
		C2H2 Zn finger	627..647	CDD:275368	5/19 (26%)
		C2H2 Zn finger	661..681	CDD:275368	7/19 (37%)
		C2H2 Zn finger	690..710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	717..740	CDD:275368	9/22 (41%)
		C2H2 Zn finger	750..767	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100