DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YWHAZ and 14-3-3zeta

DIOPT Version :9

Sequence 1:	NP_001129171.1	Gene:	YWHAZ / 7534	HGNCID:	12855	Length:	245	Species:	Homo sapiens
Sequence 2:	NP_001014515.1	Gene:	14-3-3zeta / 36059	FlyBaseID:	FBgn0004907	Length:	248	Species:	Drosophila melanogaster

Alignment Length:	245	Identity:	199/245 - (81%)
Similarity:	221/245 - (90%)	Gaps:	0/245 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSI 65
            :||.|||||||||||:|||||||..||||||.|.|||||||||||||||||||||||||||:|||
  Fly     4 VDKEELVQKAKLAEQSERYDDMAQAMKSVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSI 68

Human    66 EQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLA 130
            |||||.:.:|||:||||||::|.|||:||.:||.||:|:|||.||..||||||||||||||||||
  Fly    69 EQKTEASARKQQLAREYRERVEKELREICYEVLGLLDKYLIPKASNPESKVFYLKMKGDYYRYLA 133

Human   131 EVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTA 195
            |||.||.:..:||.||.|||:||:|||.:||||||||||||||||||||||||||:|||.|||.|
  Fly   134 EVATGDARNTVVDDSQTAYQDAFDISKGKMQPTHPIRLGLALNFSVFYYEILNSPDKACQLAKQA 198

Human   196 FDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN 245
            ||:||||||||:|:|||||||||||||||||||||||||||||..|||:|
  Fly   199 FDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDEAEPQEGGDN 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YWHAZ	NP_001129171.1	14-3-3_beta_zeta	2..230	CDD:206758	185/227 (81%)
14-3-3zeta	NP_001014515.1	14-3-3	5..234	CDD:413191	186/228 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	363	1.000	Domainoid score	I947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56528
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1934
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S35
OMA	1	1.010	-	-		QHG53683
OrthoDB	1	1.010	-	-		D1176818at2759
OrthoFinder	1	1.000	-	-		FOG0000128
OrthoInspector	1	1.000	-	-		otm40695
orthoMCL	1	0.900	-	-		OOG6_100283
Panther	1	1.100	-	-	O	PTHR18860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1059
SonicParanoid	1	1.000	-	-		X206
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.960