DRSC/TRiP Functional Genomics Resources

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Protein Alignment YY1 and CG2120

DIOPT Version :10

Sequence 1:NP_003394.1 Gene:YY1 / 7528 HGNCID:12856 Length:414 Species:Homo sapiens
Sequence 2:NP_572446.2 Gene:CG2120 / 31737 FlyBaseID:FBgn0030005 Length:315 Species:Drosophila melanogaster


Alignment Length:182 Identity:55/182 - (30%)
Similarity:78/182 - (42%) Gaps:35/182 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   253 EYMTGKKLP-------PGGIPGIDLSD---------------PKQLAEFARMKPRKIKEDDAPRT 295
            |.::|::||       ||.  ..||.:               |..:.     ||::.......||
  Fly    37 EDLSGERLPMEMELLNPGS--EYDLLELVNGALQQRNTTEHKPTDMC-----KPKRTPTTKRHRT 94

Human   296 IACPHKG--CTKMFRDNSAMRKHLHTH-GPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTF 357
            ....|..  |.:.|.:...:|.|..|| ..:.|||.||||.|.:.:||:.|.:.||.|:|.:|..
  Fly    95 TGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDI 159

Human   358 EGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHI-LTHA 408
              |||.|.....|..|.|:|||::||.|....|:..|......:.|. |.||
  Fly   160 --CGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHA 209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
YY1NP_003394.1 Interaction with the SMAD1/SMAD4 complex. /evidence=ECO:0000269|PubMed:15329343 1..170
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..81
Gly-rich region involved in interaction with HCFC1. /evidence=ECO:0000269|PubMed:20805357 116..260 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 157..203
Involved in nuclear matrix association. /evidence=ECO:0000269|PubMed:9493912 257..341 28/108 (26%)
COG5048 <268..407 CDD:227381 47/157 (30%)
Binding to DNA. /evidence=ECO:0000269|PubMed:18950698 295..414 43/118 (36%)
C2H2 Zn finger 298..320 CDD:275368 5/23 (22%)
C2H2 Zn finger 327..347 CDD:275368 9/19 (47%)
Involved in repression of activated transcription 333..371 13/37 (35%)
C2H2 Zn finger 355..377 CDD:275368 8/21 (38%)
Involved in masking transactivation domain 371..397 10/25 (40%)
C2H2 Zn finger 385..407 CDD:275368 5/22 (23%)
CG2120NP_572446.2 C2H2 Zn finger 101..121 CDD:275368 4/19 (21%)
C2H2 Zn finger 129..149 CDD:275368 9/19 (47%)
COG5048 151..>264 CDD:227381 22/61 (36%)
C2H2 Zn finger 157..177 CDD:275368 8/21 (38%)
C2H2 Zn finger 185..206 CDD:275368 4/20 (20%)
C2H2 Zn finger 235..255 CDD:275368
C2H2 Zn finger 263..285 CDD:275368
C2H2 Zn finger 293..313 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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