Protein Alignment XRCC5 and YKU80

DIOPT Version :10

• Sequence 1: XP_054199770.1
• Gene: XRCC5 / 7520
• HGNCID: 12833
• Length: 827
• Species: Homo sapiens
• Sequence 2: NP_013824.1
• Gene: YKU80 / 855132
• SGDID: S000004712
• Length: 629
• Species: Saccharomyces cerevisiae
• Alignment Length: 693
• Identity: 134/693 - (19%)
• Similarity: 234/693 - (33%)
• Gaps: 260/693 - (37%)

Human   187 EDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKR----HIEIFTDLSSRFSKSQLDIIIH 247
            |.::|.||         ..|:||:|:.|      :|:.|    .|.:|||     :...|||...
Yeast   101 EGLQSMIQ---------CLLVVSLDIKQ------QFQARKILKQIVVFTD-----NLDDLDITDE 145

Human   248 SLKKC--DISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEG--LEIVKMVMI 308
            .:...  ::|.:..| ...||:                        ..|::|:.  |::|:.:..
Yeast   146 EIDLLTEELSTRIIL-IDCGKD------------------------TQEERKKSNWLKLVEAIPN 185

Human   309 SLEGEDGLDEIYSFSESLRKL-----CVFKKIERHSIHWPCRLTIGSN----------------- 351
            |        .||:.:|.|.::     .|.|.:...|    ..|.:|::
Yeast   186 S--------RIYNMNELLVEITSPATSVVKPVRVFS----GELRLGADILSTQTSNPSGSMQDEN 238

Human   352 -LSIRIAAYKSILQERVKKTWTVVDAKT-LKKEDIQKETVYC------------------LNDDD 396
             |.|::.|:.:      .|..:.::.|| ::.||.||:..|.                  :::||
Yeast   239 CLCIKVEAFPA------TKAVSGLNRKTAVEVEDSQKKERYVGVKSIIEYEIHNEGNKKNVSEDD 297

Human   397 ET-------EVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKS-EGKCFSVLGFCKSSQVQRRFFMG 453
            ::       .:.|:.:.:.:|||:|.|....|..:|..|:| .|  ..:.||.....:.|.|...
Yeast   298 QSGSSYIPVTISKDSVTKAYRYGADYVVLPSVLVDQTVYESFPG--LDLRGFLNREALPRYFLTS 360

Human   454 NQVLKVFAARDD----EAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFP----HIKHN 510
            .   ..|...|.    ::..:|.|:|:..:.:...:|:.||...|.:...:....|    |...|
Yeast   361 E---SSFITADTRLGCQSDLMAFSALVDVMLENRKIAVARYVSKKDSEVNMCALCPVLIEHSNIN 422

Human   511 YE-----CLVYVQLPFMEDLRQYMFSSL--KNSKKYAPTEAQLNA--VDAL----IDSMSLAKKD 562
            .|     .|...:|||.||.|...|..|  :.:....|.:.:.:.  :|.|    :|||.
Yeast   423 SEKKFVKSLTLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFVDSMD----- 482

Human   563 EKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSK 627
              ||.|                           |..||       .|...|..||||.:.:||..
Yeast   483 --TDEL---------------------------PEIPL-------GNYYQPIGEVTTDTTLPLPS 511

Human   628 IKTLFPLIEAKKKDQVTAQEIFQDNHEDG---PTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNP 689
            :          .|||       ::|.:|.   ||.
Yeast   512 L----------NKDQ-------EENKKDPLRIPTV------------------------------ 529

Human   690 AENFRVLVKQKKASFEEASNQLINHIEQF--------LDTNETPYFMKSIDCIRAFREEAIKFSE 746
                 .:.:|::...|.....:||...:|        |....:||..|..|..:......||..:
Yeast   530 -----FVYRQQQVLLEWIHQLMINDSREFEIPELPDSLKNKISPYTHKKFDSTKLVEVLGIKKVD 589

Human   747 EQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGS 789
            :.:.::.||...|:.:|..|    |.:::.|     ::.:.||
Yeast   590 KLKLDSELKTELEREKIPDL----ETLLKRG-----EQHSRGS 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XRCC5	XP_054199770.1	Ku_N	104..339	CDD:427470	33/164 (20%)
		KU80	339..638	CDD:238445	73/364 (20%)
		Ku_PK_bind	688..801	CDD:462604	21/110 (19%)
YKU80	NP_013824.1	Ku_N	5..232	CDD:427470	36/187 (19%)
		KU80	244..583	CDD:238445	85/442 (19%)