Protein Alignment XRCC5 and xrcc5

DIOPT Version :10

• Sequence 1: XP_054199770.1
• Gene: XRCC5 / 7520
• HGNCID: 12833
• Length: 827
• Species: Homo sapiens
• Sequence 2: NP_001017360.2
• Gene: xrcc5 / 449848
• ZFINID: ZDB-GENE-041008-108
• Length: 727
• Species: Danio rerio
• Alignment Length: 735
• Identity: 420/735 - (57%)
• Similarity: 560/735 - (76%)
• Gaps: 11/735 - (1%)

Human    96 MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTD 160
            |.|:. |:|:||||||||:||||.||.|.|||||||||..||||||||||||||.|||||||||.
Zfish     1 MARAA-KSALVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTK 64

Human   161 NPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKR 225
            |||:...||:|||||||||:|||:|||:||.::|||.||||:||||:|.||::|:||:|||:::.
Zfish    65 NPLANDGQYENITVHRHLMIPDFELLEEIERELQPGGQQADWLDALVVCMDLLQNETMGKKYDRL 129

Human   226 HIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD--GPFRLGGHGPSFP 288
            :|.:.|||:.:.|:.||||||.:|||..|:|||||||.:..||.:|..||  ||    ...||.|
Zfish   130 NIALLTDLNIQTSEDQLDIIIQNLKKAGITLQFFLPFPVDVEDEAGGGGDAAGP----SAPPSRP 190

Human   289 LKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLS 353
            .||::.||.:|||:||.:|.|||.||||:|:|:||::|.||.:||:|||..:.|||:|||||:||
Zfish   191 GKGLSRQQTQGLEMVKHIMSSLEDEDGLEEVYTFSDALEKLSIFKRIERRPMAWPCQLTIGSSLS 255

Human   354 IRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPF 418
            |||..||::.:|:|||:||:|||::.:::|:::||||||||||||||.|:|.|||:|||||||||
Zfish   256 IRIVGYKAVTEEKVKKSWTIVDAQSHQRDDVKRETVYCLNDDDETEVQKDDTIQGYRYGSDIVPF 320

Human   419 SKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLD 483
            |||||||||||.:|||||||||.|...:.|..|||:||:||||.||||.|||||||||.|||.|.
Zfish   321 SKVDEEQMKYKHDGKCFSVLGFTKQELIPRHQFMGSQVVKVFAPRDDEHAAVALSSLIRALDGLK 385

Human   484 MVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNA 548
            |.||||||||:|:|||||.|||.||..||||:|||||:||||||:.|..|:|:||:.|:.:||:|
Zfish   386 MAAIVRYAYDRRSNPQVGAAFPCIKKKYECLLYVQLPYMEDLRQFTFPMLENNKKFMPSGSQLSA 450

Human   549 VDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNP 613
            ||||||||.|.:|||..:::| :|....||||:||||||||.||.::|.:||||:...:..:|..
Zfish   451 VDALIDSMMLMEKDENGESVE-IFKVNHIPNPQFQRLFQCLHHRGVNPDDPLPPVDPWLKRVLER 514

Human   614 PAEVTTKSQIPLSKIKTLFPL-IEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLA 677
            |..|:.:.|.||..:||.||| :..|||:|.|:.::| .:..|.|.|||:|..: ...|:::.:.
Zfish   515 PQAVSARCQAPLRDVKTSFPLKVVVKKKEQKTSADVF-GSSADEPDAKKVKVNE-ETEFNLAEIT 577

Human   678 EGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAI 742
            ||::|||||||||.:|..|::||..||::|..||.:.|||.|....|.|:.|||.||:|||::::
Zfish   578 EGNITSVGSVNPARDFCTLIRQKTVSFDQACQQLTHRIEQLLGNRSTEYYTKSIACIQAFRDQSV 642

Human   743 KFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPS 807
            .....:.||::|::|:..:..:.|..||.::.||.:|||:|:|...|:::.:||.:||:.:.|..
Zfish   643 LSGNAELFNSYLQSLKRSIADRSLQDFWNLLAQDALTLISKDEVEASTISKQEANQFLSFEQKQE 707

Human   808 GDTAAVFEEGGDVDDLLDMI 827
            .:.|...::.|||||||||:
Zfish   708 VEVAPAQDDTGDVDDLLDMM 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XRCC5	XP_054199770.1	Ku_N	104..339	CDD:427470	151/236 (64%)
		KU80	339..638	CDD:238445	189/299 (63%)
		Ku_PK_bind	688..801	CDD:462604	44/112 (39%)
xrcc5	NP_001017360.2	vWFA	6..231	CDD:469594	145/228 (64%)
		KU80	241..535	CDD:238445	187/294 (64%)
		Ku_PK_bind	588..701	CDD:462604	44/112 (39%)