Protein Alignment XRCC5 and Xrcc5

DIOPT Version :10

• Sequence 1: XP_054199770.1
• Gene: XRCC5 / 7520
• HGNCID: 12833
• Length: 827
• Species: Homo sapiens
• Sequence 2: NP_803154.2
• Gene: Xrcc5 / 363247
• RGDID: 3976
• Length: 732
• Species: Rattus norvegicus
• Alignment Length: 733
• Identity: 574/733 - (78%)
• Similarity: 639/733 - (87%)
• Gaps: 2/733 - (0%)

Human    96 MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTD 160
            |..||||||||||||||..|.||.||.|||.||||||:|||||||||:|:||||||||:||:.||
  Rat     1 MAWSGNKAAVVLCMDVGVAMGNSFPGEESPLEQAKKVMTMFVQRQVFSESKDEIALVLYGTESTD 65

Human   161 NPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKR 225
            |.|:|.|||||||||||||||||||||||.:||||.||||||||||||.||:||.|||||||.|:
  Rat    66 NALAGKDQYQNITVHRHLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKKFGKK 130

Human   226 HIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLK 290
            |||:||||||.||:.||||||.:|||..|||||||||.:.|....|:..|.........||||.|
  Rat   131 HIEVFTDLSSPFSQDQLDIIICNLKKSSISLQFFLPFPIDKNGEPGETEDHDSSFDHCAPSFPQK 195

Human   291 GITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIR 355
            |:|||||||:.:|..||:||||:|||||||||||||::||:||||||.|:.|||:||||.|||||
  Rat   196 GLTEQQKEGIHMVTRVMLSLEGKDGLDEIYSFSESLQQLCIFKKIERRSLPWPCQLTIGPNLSIR 260

Human   356 IAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSK 420
            |.|||||:||:.||:|.||||:|||||||||||||||||||||||.|||.||||||||||:||||
  Rat   261 IVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCLNDDDETEVSKEDTIQGFRYGSDIIPFSK 325

Human   421 VDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMV 485
            ||||||||||||||||||||||||||.||||||:||||||||:||||||||||||:||||:|:||
  Rat   326 VDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVLKVFAAKDDEAAAVALSSLVHALDELNMV 390

Human   486 AIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVD 550
            ||||||||||||||||||||.||..|||||||||||||||||||||||||:||..||||||:|:|
  Rat   391 AIVRYAYDKRANPQVGVAFPFIKDAYECLVYVQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAID 455

Human   551 ALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPA 615
            .|||||||.||:|:.|.:||||||:|||||.||||:|||||||||.:|.||||||||.|||:||.
  Rat   456 DLIDSMSLVKKNEEEDIIEDLFPTSKIPNPEFQRLYQCLLHRALHLQERLPPIQQHILNMLDPPT 520

Human   616 EVTTKSQIPLSKIKTLFPLIE-AKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEG 679
            |:..|.:|||||:||||||.| .|||||||||::||||.|:||.|||.|||:...|.|:||||||
  Rat   521 EMKAKCEIPLSKVKTLFPLTEVVKKKDQVTAQDVFQDNIEEGPAAKKYKTEKEEGHISISSLAEG 585

Human   680 SVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKF 744
            :||.||||||.|||||||:||.|||||||.||::|||||||||||.|||||:|||:|.|||||:|
  Rat   586 NVTKVGSVNPVENFRVLVRQKIASFEEASLQLMSHIEQFLDTNETLYFMKSMDCIKALREEAIQF 650

Human   745 SEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGD 809
            |||||||:||:.|:|||||||||||||||||||||||||:|:.|||||||||.|||.||||...|
  Rat   651 SEEQRFNSFLEGLREKVEIKQLNHFWEIVVQDGITLITKDESPGSSVTAEEATKFLTPKDKAKED 715

Human   810 TAAVFEEGGDVDDLLDMI 827
            |..: |||||||||||||
  Rat   716 TTGL-EEGGDVDDLLDMI 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XRCC5	XP_054199770.1	Ku_N	104..339	CDD:427470	172/234 (74%)
		KU80	339..638	CDD:238445	247/299 (83%)
		Ku_PK_bind	688..801	CDD:462604	93/112 (83%)
Xrcc5	NP_803154.2	Ku_N	9..244	CDD:427470	172/234 (74%)
		KU80	246..542	CDD:238445	245/295 (83%)
		Ku_PK_bind	594..707	CDD:462604	93/112 (83%)